MOLECULAR-CLONING, SEQUENCE-ANALYSIS AND CODING ASSIGNMENT OF THE MAJOR INNER CAPSID PROTEIN GENE OF HUMAN GROUP-C ROTAVIRUS

被引：19

作者：

COOKE, SJ ^{[1
]}

LAMBDEN, PR ^{[1
]}

CAUL, EO ^{[1
]}

CLARKE, IN ^{[1
]}

机构：

[1] PUBL HLTH LAB,REG VIRUS LAB,BRISTOL BS2 8EL,ENGLAND

来源：

VIROLOGY | 1991年 / 184卷 / 02期

关键词：

D O I：

10.1016/0042-6822(91)90452-H

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The VP6 gene of human group C rotavirus was cloned and sequenced. Hybridization to the human group C and the porcine group C/Cowden dsRNA genomes assigned this coding sequence to segment 5. The complete human VP6 sequence contained an open reading frame of 1185 nucleotides (395 amino acids; deduced Mr 44,669 Da). The protein sequence demonstrated low homology with the group A VP6 sequences (41.7 to 42.7%) and high homology (88.9%) with the porcine group C VP6 sequence. However, the protein sequence alignments revealed a region of 10 amino acids that were significantly different between the human and the porcine group C viruses. © 1991.

引用

页码：781 / 785

页数：5

共 32 条

[1] PORCINE PARAROTAVIRUS - DETECTION, DIFFERENTIATION FROM ROTAVIRUS, AND PATHOGENESIS IN GNOTOBIOTIC PIGS [J].