INTERLEUKIN-2 SUPPRESSES ESTABLISHED LONG-TERM POTENTIATION AND INHIBITS ITS INDUCTION IN THE RAT HIPPOCAMPUS

被引：117
作者：
TANCREDI, V
ZONA, C
VELOTTI, F
EUSEBI, F
SANTONI, A
机构：
[1] UNIV ROME LA SAPIENZA,DIPARTIMENTO MED SPERIMENTALE,I-00185 ROME,ITALY
[2] UNIV LAQUILA,DEPT MED SPERIMENTALE,I-67100 LAQUILA,ITALY
来源：
BRAIN RESEARCH | 1990年 / 525卷 / 01期
关键词：
Hippocampal slice; Interleukin-2; Long-term potentiation;
D O I：
10.1016/0006-8993(90)91331-A
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of recombinant interleukin-2 (rIL-2) on teh potentiation of thesynaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed. © 1990.
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收藏
页码：149 / 151
页数：3
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