5-HT3 receptor antagonists for the treatment of nausea/vomiting

被引：44
|
作者：
Smith, Howard S. [1 ]
Cox, Lorraine R. [2 ]
Smith, Eric J.
机构：
[1] Dept Anesthesiol, Albany, NY 12208 USA
[2] Albany Med Ctr Hosp, Palliat Med Serv, Albany, NY 12208 USA
来源：
ANNALS OF PALLIATIVE MEDICINE | 2012年 / 1卷 / 02期
关键词：
Nausea/Vomiting; 5-HT3; antagonists; serotonin; chemotherapy-induced nausea/vomiting; postoperative nausea/vomiting; palonostron; ondansetron;
D O I：
10.3978/j.issn.2224-5820.2012.07.07
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
It is well appreciated that a number of things (e.g., various insults, chemotherapeutic agents, radiation) may lead to the release of serotonin from the enterochromaffin of the gastrointestinal tract. Released serotonin may then bind to certain 5-HT3 receptors and promote nausea/vomiting. 5-HT3 receptor antagonists may ameliorate nausea/vomiting in a number of circumstances and have been utilized as important antiemetics for multiple conditions such as chemotherapy-induced nausea/vomiting (CINV), radiation-induced emesis (RIS), and postoperative nausea/vomiting (PONV).
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页码：115 / 120
页数：6
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