PROTECTION OF GUINEA-PIGS AGAINST FOOT-AND-MOUTH-DISEASE VIRUS BY IMMUNIZATION WITH A PHOE FMDV HYBRID PROTEIN

被引：13
作者：
AGTERBERG, M
ADRIAANSE, H
BARTELING, S
VANMAANEN, K
TOMMASSEN, J
机构：
[1] STATE UNIV UTRECHT,INST MOLEC BIOL & MED BIOTECHNOL,PADUALAAN 8,3584 CH UTRECHT,NETHERLANDS
[2] CENT VET INST,8221 RA LELYSTAD,NETHERLANDS
[3] STATE UNIV UTRECHT,DEPT MOLEC CELL BIOL,3584 CH UTRECHT,NETHERLANDS
来源：
VACCINE | 1990年 / 8卷 / 05期
关键词：
carrier system; foot-and-mouth disease virus; PhoE protein; vaccine;
D O I：
10.1016/0264-410X(90)90242-E
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A hybrid protein was constructed containing two antigenic determinants of the structural protein VPI of foot-and-mouth disease virus, inserted in a cell surface-exposed region of Escherichia coli outer membrane protein PhoE. Immunization of guinea-pigs with partially purified protein resulted in high levels of neutralizing antibodies and complete protection against challenge with the virus. © 1990.
引用
收藏
页码：438 / 440
页数：3
相关论文
共 20 条
[1]   INSERTION MUTAGENESIS ON A CELL-SURFACE-EXPOSED REGION OF OUTER-MEMBRANE PROTEIN PHOE OF ESCHERICHIA-COLI K-12 [J].
AGTERBERG, M ;
BENZ, R ;
TOMMASSEN, J .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 169 (01) :65-71
[2]   USE OF OUTER-MEMBRANE PROTEIN PHOE AS A CARRIER FOR THE TRANSPORT OF A FOREIGN ANTIGENIC DETERMINANT TO THE CELL-SURFACE OF ESCHERICHIA-COLI K-12 [J].
AGTERBERG, M ;
ADRIAANSE, H ;
TOMMASSEN, J .
GENE, 1987, 59 (01) :145-150
[3]   OUTER-MEMBRANE PHOE PROTEIN OF ESCHERICHIA-COLI AS A CARRIER FOR FOREIGN ANTIGENIC DETERMINANTS - IMMUNOGENICITY OF EPITOPES OF FOOT-AND-MOUTH-DISEASE VIRUS [J].
AGTERBERG, M ;
ADRIAANSE, H ;
LANKHOF, H ;
MELOEN, R ;
TOMMASSEN, J .
VACCINE, 1990, 8 (01) :85-91
[4]  
AGTERBERG M, 1988, FEMS MICROBIOL LETT, V50, P295
[5]   PERMEATION OF HYDROPHILIC MOLECULES THROUGH THE OUTER-MEMBRANE OF GRAM-NEGATIVE BACTERIA - REVIEW ON BACTERIAL PORINS [J].
BENZ, R ;
BAUER, K .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 176 (01) :1-19
[6]   PROTECTION AGAINST FOOT-AND-MOUTH-DISEASE BY IMMUNIZATION WITH A CHEMICALLY SYNTHESIZED PEPTIDE PREDICTED FROM THE VIRAL NUCLEOTIDE-SEQUENCE [J].
BITTLE, JL ;
HOUGHTEN, RA ;
ALEXANDER, H ;
SHINNICK, TM ;
SUTCLIFFE, JG ;
LERNER, RA ;
ROWLANDS, DJ ;
BROWN, F .
NATURE, 1982, 298 (5869) :30-33
[7]  
DELEEUW PW, 1979, ZBL VET MED B, V26, P85
[8]   PROTECTION OF CATTLE AGAINST FOOT-AND-MOUTH-DISEASE BY A SYNTHETIC PEPTIDE [J].
DIMARCHI, R ;
BROOKE, G ;
GALE, C ;
CRACKNELL, V ;
DOEL, T ;
MOWAT, N .
SCIENCE, 1986, 232 (4750) :639-641
[9]  
HERBERT WJ, 1965, LANCET, V2, P771
[10]   ROLE OF THE ARG158 RESIDUE OF THE OUTER-MEMBRANE PHOE PORE PROTEIN OF ESCHERICHIA-COLI K-12 IN BACTERIOPHAGE-TC45 RECOGNITION AND IN CHANNEL CHARACTERISTICS [J].
KORTELAND, J ;
OVERBEEKE, N ;
DEGRAAFF, P ;
OVERDUIN, P ;
LUGTENBERG, B .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 152 (03) :691-697
12