KINETICS OF CAFFEINE METABOLISM IN CONTROL AND 3-METHYLCHOLANTHRENE INDUCED RAT-LIVER MICROSOMES

被引：16

作者：

BONATI, M

CELARDO, A

GALLETTI, F

LATINI, R

TURSI, F

BELVEDERE, G

机构：

[1] MARIO NEGRI INST PHARMACOL RES, CLIN PHARMACOL LAB, VIA ERITREA 62, I-20157 MILAN, ITALY

[2] MARIO NEGRI INST PHARMACOL RES, ENZYME RES LAB, I-20157 MILAN, ITALY

来源：

TOXICOLOGY LETTERS | 1984年 / 21卷 / 01期

关键词：

D O I：

10.1016/0378-4274(84)90223-6

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The kinetics of formation of primary metabolites of caffeine (paraxanthine, theophylline, theobromine and 1,3,7-trimethyluric acid) was studied in control (CO) and 3-methylcholanthrene-induced (MC) rat liver microsomes. Vmax was similar but Km was 16-fold lower for total caffeine metabolism in CO and MC microsomes, respectively. Similar behavior was observed in the formation of each metabolite. Single metabolites showed different degrees of induction at nonsaturating concentrations of caffeine. Kinetics was nonlinear in CO microsomes.

引用

页码：53 / 58

页数：6

共 14 条

[1]

ALDRIDGE A, 1979, CLIN PHARMACOL THER, V25, P447

[2] STIMULATION OF CAFFEINE METABOLISM IN RAT BY 3-METHYLCHOLANTHRENE [J].