ETHANOL AND NICOTINE CONSUMPTION AND PREFERENCE IN TRANSGENIC MICE OVEREXPRESSING THE BOVINE GROWTH-HORMONE GENE

被引：18

作者：

MELISKA, CJ ^{[1
]}

BARTKE, A ^{[1
]}

VANDERGRIFF, JL ^{[1
]}

JENSEN, RA ^{[1
]}

机构：

[1] SO ILLINOIS UNIV,DEPT PSYCHOL,CARBONDALE,IL 62901

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 50卷 / 04期

关键词：

ALCOHOL; REWARD; SELF-ADMINISTRATION; 2-BOTTLE CHOICE; VULNERABILITY; DOPAMINE; SEX DIFFERENCES;

D O I：

10.1016/0091-3057(94)00345-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Transgenic mice overexpressing the phosphoenolpyruvate carboxykinase/bovine growth hormone (PEPCK/ bGH) hybrid gene and normal (nontransgenic) littermate controls (10 males + 10 females/group) were given access to tapwater and an ascending series of concentrations of ethanol (1.0-22.0%), then a similar ascending series of concentrations of nicotine (1.0-40.0 mu g/ml), in a two-bottle choice test. Male transgenic mice consumed more and exhibited greater preferences for ethanol and nicotine than control males; transgenic females consumed less and showed lower preferences for ethanol, but not nicotine, than control females. These results suggest that chronic exposure to high levels of bGH may modulate the rewarding effects of ethanol and nicotine in mice in a gender-specific fashion.

引用

页码：563 / 570

页数：8

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