INTERACTIONS BETWEEN CD4+ T-CELLS AND RAT SCHWANN-CELLS INVITRO .2. CYTOTOXIC EFFECTS OF P2-SPECIFIC CD4+ T-CELL LINES ON LEWIS RAT SCHWANN-CELLS

被引：24

作者：

ARGALL, KG ^{[1
]}

ARMATI, PJ ^{[1
]}

POLLARD, JD ^{[1
]}

BONNER, J ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT MED,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 40卷 / 01期

基金：

英国医学研究理事会;

关键词：

SCHWANN CELL; INFLAMMATORY DEMYELINATING NEUROPATHY; CD4+ T CELL LINES; MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE; CYTOTOXICITY;

D O I：

10.1016/0165-5728(92)90209-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cytotoxic effects of CD4+ P2-specific T-cell lines on Schwann cells were examined in vitro with Cr-51-release cytotoxicity assays. Only those P2-specific T-cell lines capable of inducing EAN when injected back into adult Lewis rats were cytotoxic to the Schwann cells. The addition of exogenous P2 protein was not necessary for the cytotoxic effect. The monoclonal antibody (mAb) OX6 directed against Major histocompatibility complex (MHC) class II molecules blocked cytotoxicity, indicating an essential role for MHC class II molecules in this interaction between CD4+ T-cell lines and Schwann cells.

引用

页码：19 / 30

页数：12

共 23 条

[1] USE OF MICROWAVE FIXATION IN THE PREPARATION OF CELL-CULTURES FOR OBSERVATION WITH THE SCANNING ELECTRON-MICROSCOPE [J].