IMMUNOHISTOCHEMICAL DEMONSTRATION OF THE EPSTEIN-BARR VIRUS-ENCODED LATENT MEMBRANE-PROTEIN IN PARAFFIN SECTIONS OF HODGKINS-DISEASE

被引：120

作者：

MURRAY, PG

YOUNG, LS

ROWE, M

CROCKER, J

机构：

[1] E BIRMINGHAM DIST GEN HOSP,DEPT HISTOPATHOL,BORDESLEY GREEN E,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

[2] GOOD HOPE HOSP,DEPT HISTOPATHOL,SUTTON COLDFIELD B75 7RR,W MIDLANDS,ENGLAND

[3] WOLVERHAMPTON POLYTECH,BIOMED RES LABS,WOLVERHAMPTON WV1 1DJ,ENGLAND

[4] UNIV BIRMINGHAM,SCH MED,DEPT CANC STUDIES,CANC RES CAMPAIGN LABS,BIRMINGHAM B15 2TJ,W MIDLANDS,ENGLAND

来源：

JOURNAL OF PATHOLOGY | 1992年 / 166卷 / 01期

关键词：

LATENT MEMBRANE PROTEIN; EPSTEIN-BARR VIRUS; HODGKINS DISEASE;

D O I：

10.1002/path.1711660102

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Paraffin sections from 46 cases of Hodgkin's disease were examined for the presence of the Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP) using a sensitive (double layer alkaline phosphatase-anti-alkaline phosphatase) immunohistochemical method. LMP was detected in 22 cases, the majority of positive cases being of nodular sclerosis (12/24), mixed cellularity (6/7), and lymphocyte depletion (3/3) subtypes. Only one of 12 cases of lymphocyte predominant disease was positive. In all cases, reactivity was confined to Hodgkin's and Reed-Sternberg cells. These results provide further evidence for an association between EBV and Hodgkin's disease and indicate that LMP may be readily detected in archival material.

引用

页码：1 / 5

页数：5

共 22 条

[1]

ANAGNOSTOPOULOS I, 1989, BLOOD, V74, P810

[2] EPSTEIN-BARR VIRUS LATENT INFECTION MEMBRANE-PROTEIN INCREASES VIMENTIN EXPRESSION IN HUMAN B-CELL LINES [J].