PLASMA ENDOTHELIN-1 LEVELS IN NORMOTENSIVE AND BORDERLINE HYPERTENSIVE SUBJECTS DURING A STANDARD COLD PRESSOR TEST

被引：0

作者：

LETIZIA, C ^{[1
]}

CERCI, S ^{[1
]}

DECIOCCHIS, A ^{[1
]}

DAMBROSIO, C ^{[1
]}

SCURO, L ^{[1
]}

SCAVO, D ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,ROME,ITALY

来源：

JOURNAL OF HUMAN HYPERTENSION | 1995年 / 9卷 / 11期

关键词：

ENDOTHELIN-1; COLD PRESSER TEST; HYPERTENSIVES; NORMOTENSIVES;

D O I：

暂无

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Endothelin-1 (ET-1) is a potent vasoconstrictor peptide derived from endothelium. The presence of ET-1 in human vascular endothelium and in the plasma suggests that it may play a role in the regulation of vascular tone and blood pressure (BP) in humans. The aim of this study was to evaluate the behaviour of plasma Et-1 in 10 normotensives (average 36.3+/-14.8 years) and 10 borderline hypertensives (average 42.0+/-11.7 years) before, during and after a standard cold presser test. We also evaluated the behaviour of heart rate and BP at the same time. Our results demonstrated that the baseline (-10 and 0 min) plasma ET-1 values were identical for the two groups (8.6+/-5.8 and 8+/-4.7 pg/ml in normotensives; 7.8+/-2.7 and 7+/-2.4 pg/ml in borderline hypertensives), A statistically significant increment was verified 10 min after exposure to cold in the borderline hypertensive group (12.1+/-5.1 pg/ml) compared with the normotensives roup (6.8+/-4.5 pg/ml; P<0.05). In conclusion, our study demonstrated that after 10 min of cold presser stimulus an increase of circulating ET-1 levels was seen in borderline hypertensives.

引用

页码：903 / 907

页数：5