THE RELATIONSHIP OF ANTIENDOTHELIAL CELL ANTIBODIES TO ANTIPHOSPHOLIPID ANTIBODIES IN PATIENTS WITH GIANT-CELL ARTERITIS AND/OR POLYMYALGIA-RHEUMATICA

被引：14

作者：

LETONQUEZE, M ^{[1
]}

DUEYMES, M ^{[1
]}

GIOVANGRANDI, Y ^{[1
]}

BEIGBEDER, G ^{[1
]}

JOUQUAN, J ^{[1
]}

PENNEC, YL ^{[1
]}

MOTTIER, D ^{[1
]}

LEGOFF, P ^{[1
]}

YOUINOU, P ^{[1
]}

机构：

[1] BREST UNIV MED SCH HOSP,IMMUNOL LAB,BREST,FRANCE

来源：

AUTOIMMUNITY | 1995年 / 20卷 / 01期

关键词：

GIANT CELL ARTERITIS; POLYMYALGIA RHEUMATICA; ENDOTHELIAL CELL; CARDIOLIPIN; PHOSPHATIDYLETHANOLAMINE;

D O I：

10.3109/08916939508993340

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sera from patients with giant cell arteritis and/or polymyalgia rheumatica were tested for the presence of IgG, IgM and IgA antibody to endothelial cells (AEC), cardiolipin (ACL) and phosphatidylethanolamine (APE) using enzyme-linked immunosorbent assays. There were strong correlations between ACL and APE, but also between AEC and ACL IgM (p < 0.02) and between AEC and APE IgA (p < 0.003). Inhibition of AEC binding was achieved by absorption onto EC, but ACL and APE binding was also significantly reduced. In contrast, the binding of AEC antibody could not be inhibited by incubation with CL. Our data suggest that AEC constitute a heterogeneous population of autoantibodies.

引用

页码：59 / 66

页数：8

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