THE RELATIONSHIP OF ANTIENDOTHELIAL CELL ANTIBODIES TO ANTIPHOSPHOLIPID ANTIBODIES IN PATIENTS WITH GIANT-CELL ARTERITIS AND/OR POLYMYALGIA-RHEUMATICA

被引：14

作者：

LETONQUEZE, M ^{[1
]}

DUEYMES, M ^{[1
]}

GIOVANGRANDI, Y ^{[1
]}

BEIGBEDER, G ^{[1
]}

JOUQUAN, J ^{[1
]}

PENNEC, YL ^{[1
]}

MOTTIER, D ^{[1
]}

LEGOFF, P ^{[1
]}

YOUINOU, P ^{[1
]}

机构：

[1] BREST UNIV MED SCH HOSP,IMMUNOL LAB,BREST,FRANCE

来源：

AUTOIMMUNITY | 1995年 / 20卷 / 01期

关键词：

GIANT CELL ARTERITIS; POLYMYALGIA RHEUMATICA; ENDOTHELIAL CELL; CARDIOLIPIN; PHOSPHATIDYLETHANOLAMINE;

D O I：

10.3109/08916939508993340

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sera from patients with giant cell arteritis and/or polymyalgia rheumatica were tested for the presence of IgG, IgM and IgA antibody to endothelial cells (AEC), cardiolipin (ACL) and phosphatidylethanolamine (APE) using enzyme-linked immunosorbent assays. There were strong correlations between ACL and APE, but also between AEC and ACL IgM (p < 0.02) and between AEC and APE IgA (p < 0.003). Inhibition of AEC binding was achieved by absorption onto EC, but ACL and APE binding was also significantly reduced. In contrast, the binding of AEC antibody could not be inhibited by incubation with CL. Our data suggest that AEC constitute a heterogeneous population of autoantibodies.

引用

页码：59 / 66

页数：8

共 35 条

[1]

Berthelot J.M., Lamour A., Mottier D., Pennec Y.L., Dueymes M., Jouquan J., Et al., Anti-neutrophil cytoplasm antibodies in patients with giant cell arteritis and/or polymyalgia rheumatica, Ann Med Int, 143, pp. 429-432, (1992)

[2]

Hazleman B.I., MacLenman I.C.M., Esiri M.M., Lymphocyte proliferation to artery antigens as a positive diagnostic tool in polymyalgia rheumatica, Ann Rheum Dis, 34, pp. 122-127, (1975)

[3]

Lindquist R.J., Osterland C.K., Human antibodies to vascular endothelium, Clin Exp Immunol, 9, pp. 753-760, (1971)

[4]

Tan E.M., Pearson C.M., Rheumatic diseases with sera reactive with capillaries in the mouse kidney, Arthritis Rheum, 15, pp. 23-28, (1972)

[5]

Paul L.C., Claas F.H.J., van Es L.A., Kaff M.W., de Graeff J., Accelerated rejection of a renal allgraft associated with pretransplantation antibodies directed against donor antigens on endothelium and monocytes, N Engl J Med, 300, pp. 1258-1260, (1979)

[6]

Burns E.R., Zucker-Franklin D., Pathologic effects of plasma from patients with thrombotic thrombocytopenic purpura on platelets and cultured endothelial cells, Blood, 60, pp. 1030-1037, (1982)

[7]

Leung P.Y.M., Collins T., Lapierre L.A., Geha R.S., IgM antibodies present in the acute phase of the Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon, J Clin Invest, 77, pp. 1428-1435, (1986)

[8]

Leung P.Y.M., Moake J.L., Havens P.L., Kim M., Pober J.S., Lytic anti-endothelial cell antibodies in haemolytic-uremic syndrome, Lancet, 2, pp. 183-186, (1988)

[9]

Rosenbaum J., Pottinger B.E., Woo P., Black C.M., Loigou S., Byron M.A., Et al., Measurement and characterization of circulating anti-endothelial cell IgG in connective tissue diseases, Clin Exp Immunol, 72, pp. 450-456, (1988)

[10]

Brasile L., Kremer J.L., Clarke J.L., Identification of on autoantibody to vascular endothelial cell-specific antigens in patients with systemic vasculitis, Am J Med, 87, pp. 74-80, (1989)

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