P15(INK4B) IS A POTENTIAL EFFECTOR OF TGF-BETA-INDUCED CELL-CYCLE ARREST

被引：1920
作者：
HANNON, GJ [1 ]
BEACH, D [1 ]
机构：
[1] COLD SPRING HARBOR LAB,HOWARD HUGHES MED INST,COLD SPRING HARBOR,NY 11724
来源：
NATURE | 1994年 / 371卷 / 6494期
关键词：
D O I：
10.1038/371257a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
TRANSFORMING growth factor-beta (TGF-beta) inhibits cell proliferation by inducing a G1-phase cell cycle arrest(1). Normal progression through G1 is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6 (ref. 2), which are inhibited by the protein p16(INK4). We have isolated a new member of the p16(INK4) family, p15(INK4B). p15 expression is induced similar to 30-fold in human keratinocytes by treatment with TGF-beta, suggesting that p15 may act as an effector of TGF-beta-mediated cell cycle arrest. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21).
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页码：257 / 261
页数：5
相关论文
共 28 条
  • [1] BATES S, 1994, ONCOGENE, V9, P71
  • [2] BELLO MJ, 1994, GENE CHROMOSOME CANC, V9, P33
  • [3] NORMAL KERATINIZATION IN A SPONTANEOUSLY IMMORTALIZED ANEUPLOID HUMAN KERATINOCYTE CELL-LINE
    BOUKAMP, P
    PETRUSSEVSKA, RT
    BREITKREUTZ, D
    HORNUNG, J
    MARKHAM, A
    FUSENIG, NE
    [J]. JOURNAL OF CELL BIOLOGY, 1988, 106 (03) : 761 - 771
  • [4] ASSIGNMENT OF A LOCUS FOR FAMILIAL MELANOMA, MLM, TO CHROMOSOME-9P13-P22
    CANNONALBRIGHT, LA
    GOLDGAR, DE
    MEYER, LJ
    LEWIS, CM
    ANDERSON, DE
    FOUNTAIN, JW
    HEGI, ME
    WISEMAN, RW
    PETTY, EM
    BALE, AE
    OLOPADE, OI
    DIAZ, MO
    KWIATKOWSKI, DJ
    PIEPKORN, MW
    ZONE, JJ
    SKOLNICK, MH
    [J]. SCIENCE, 1992, 258 (5085) : 1148 - 1152
  • [5] CHENG JQ, 1993, CANCER RES, V53, P4761
  • [6] TGF-BETA INHIBITION OF CDK4 SYNTHESIS IS LINKED TO CELL-CYCLE ARREST
    EWEN, ME
    SLUSS, HK
    WHITEHOUSE, LL
    LIVINGSTON, DM
    [J]. CELL, 1993, 74 (06) : 1009 - 1020
  • [7] HOMOZYGOUS DELETIONS WITHIN HUMAN-CHROMOSOME BAND-9P21 IN MELANOMA
    FOUNTAIN, JW
    KARAYIORGOU, M
    ERNSTOFF, MS
    KIRKWOOD, JM
    VLOCK, DR
    TITUSERNSTOFF, L
    BOUCHARD, B
    VIJAYASARADHI, S
    HOUGHTON, AN
    LAHTI, J
    KIDD, VJ
    HOUSMAN, DE
    DRACOPOLI, NC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10557 - 10561
  • [8] TRANSFORMING GROWTH-FACTOR-BETA EFFECTS ON EXPRESSION OF G(1) CYCLINS AND CYCLIN-DEPENDENT PROTEIN-KINASES
    GENG, Y
    WEINBERG, RA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) : 10315 - 10319
  • [9] ISOLATION OF THE RB-RELATED P130 THROUGH ITS INTERACTION WITH CDK2 AND CYCLINS
    HANNON, GJ
    DEMETRICK, D
    BEACH, D
    [J]. GENES & DEVELOPMENT, 1993, 7 (12A) : 2378 - 2391
  • [10] A CELL-CYCLE REGULATOR POTENTIALLY INVOLVED IN GENESIS OF MANY TUMOR TYPES
    KAMB, A
    GRUIS, NA
    WEAVERFELDHAUS, J
    LIU, QY
    HARSHMAN, K
    TAVTIGIAN, SV
    STOCKERT, E
    DAY, RS
    JOHNSON, BE
    SKOLNICK, MH
    [J]. SCIENCE, 1994, 264 (5157) : 436 - 440
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