BIOLOGIC DIFFERENCES BETWEEN EARLY-ONSET AND LATE-ONSET ALZHEIMER-DISEASE

被引:0
作者
TERRY, RD
机构
关键词
ALZHEIMER DISEASE; PREMORBID AGING; BRAIN;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Large neurons shrink and synapses are lost in the neocortex as a function of normal aging, but different parts of the central nervous system vary in susceptibility to age changes. Thus, early-onset disease may appear different from late cases due to premorbid age changes rather than because of different pathogenesis.
引用
收藏
页码:S26 / S27
页数:2
相关论文
共 7 条
[1]   NEOCORTICAL MORPHOMETRY, LESION COUNTS, AND CHOLINE-ACETYLTRANSFERASE LEVELS IN THE AGE SPECTRUM OF ALZHEIMERS-DISEASE [J].
HANSEN, LA ;
DETERESA, R ;
DAVIES, P ;
TERRY, RD .
NEUROLOGY, 1988, 38 (01) :48-54
[2]   NEURONAL POPULATIONS IN HUMAN BRAIN [J].
KONIGSMARK, BW ;
MURPHY, EA .
NATURE, 1970, 228 (5278) :1335-+
[3]   QUANTITATIVE SYNAPTIC ALTERATIONS IN THE HUMAN NEOCORTEX DURING NORMAL AGING [J].
MASLIAH, E ;
MALLORY, M ;
HANSEN, L ;
DETERESA, R ;
TERRY, RD .
NEUROLOGY, 1993, 43 (01) :192-197
[4]   AGING AND EXTRAPYRAMIDAL FUNCTION [J].
MCGEER, PL ;
MCGEER, EG ;
SUZUKI, JS .
ARCHIVES OF NEUROLOGY, 1977, 34 (01) :33-35
[5]   OPERATIONAL CRITERIA FOR SENILE DEMENTIA OF LEWY BODY TYPE (SDLT) [J].
MCKEITH, IG ;
PERRY, RH ;
FAIRBAIRN, AF ;
JABEEN, S ;
PERRY, EK .
PSYCHOLOGICAL MEDICINE, 1992, 22 (04) :911-922
[6]   CORTICAL NEURONAL COUNTS IN NORMAL ELDERLY CONTROLS AND DEMENTED PATIENTS [J].
MOUNTJOY, CQ ;
ROTH, M ;
EVANS, NJR ;
EVANS, HM .
NEUROBIOLOGY OF AGING, 1983, 4 (01) :1-11
[7]   NEOCORTICAL CELL COUNTS IN NORMAL HUMAN ADULT AGING [J].
TERRY, RD ;
DETERESA, R ;
HANSEN, LA .
ANNALS OF NEUROLOGY, 1987, 21 (06) :530-539