STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANALOGS OF HIGHLY POTENT OPIOID PEPTIDE BIPHALIN

被引：0

作者：

MISICKA, A

LIPKOWSKI, AW

HORVATH, R

DAVIS, P

PORRECA, F

YAMAMURA, HI

HRUBY, VJ

机构：

[1] UNIV ARIZONA,DEPT PHARMACOL,TUCSON,AZ 85721

[2] WARSAW UNIV,DEPT CHEM,PL-02093 WARSAW,POLAND

[3] POLISH ACAD SCI,MED RES CTR,PL-00784 WARSAW,POLAND

来源：

REGULATORY PEPTIDES | 1994年

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For SAR study of biphalin [(Tyr-D-Ala-Gly-PheNH-)(2)] we have synthesized several analogues with modifications of amino acid residues in position 3 and 4. The introduction of halogenated phenylalanine residues in position 4 increases affinity to delta receptors. Introducing basic aromatic amino acid residues in position 4 resulted in decrease in affinity to mu receptors, but preserve affinity to delta receptors.

引用

页码：S131 / S132

页数：2

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