ALU FAMILY VARIATIONS IN NEOPLASIA

被引：5

作者：

FILATOV, LV ^{[1
]}

MAMAYEVA, SE ^{[1
]}

TOMILIN, NV ^{[1
]}

机构：

[1] ACAD SCI USSR,INST CYTOL,TIKCHORETSKII AV 4,LELINGRAD 194064,USSR

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 56卷 / 01期

关键词：

D O I：

10.1016/0165-4608(91)90357-Z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human chromosomes contain about one million copies of dispersed repeats of the Alu family which are distributed non-randomly. In this study we have compared the pattern of hybridization of tritiated Alu-probes on chromosomes of PHA-stimulated lymphocytes of normal donors and of non-stimulated bone marrow cells of acute leukemia patients, and found regular differences in this pattern over some chromosome bands (3q26, 8p11-p12, 14q24, 15q21, 6q22) between normal individuals and leukemia patients. These data were interpreted as indicative of somatic variation of the Alu family in acute leukemia. Possible mechanisms of the variation and the role of the Alu family in chromosome rearrangements in neoplasia are discussed.

引用

页码：11 / 22

页数：12

共 48 条

[1] CYTOGENETIC EFFECTS OF RADIOTHERAPY - BREAKPOINT DISTRIBUTION IN INDUCED CHROMOSOME-ABERRATIONS [J].

BARRIOS, L ;

MIRO, R ;

CABALLIN, MR ;

FUSTER, C ;

GUEDEA, F ;

SUBIAS, A ;

EGOZCUE, J .

CANCER GENETICS AND CYTOGENETICS, 1989, 41 (01) :61-70

[2] STUDIES ON HSAG, A MIDDLE REPETITIVE FAMILY OF GENETIC ELEMENTS WHICH ELICIT A LEUKEMIA-RELATED CELLULAR-SURFACE ANTIGEN [J].

BEITEL, LK ;

CHAMBERLAIN, JW ;

BENCHIMOL, S ;

LAM, T ;

PRICE, GB ;

STANNERS, CP .

NUCLEIC ACIDS RESEARCH, 1986, 14 (08) :3391-3408

[3] SOURCES AND EVOLUTION OF HUMAN ALU REPEATED SEQUENCES [J].

BRITTEN, RJ ;

BARON, WF ;

STOUT, DB ;

DAVIDSON, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) :4770-4774

[4]

CALABRETTA B, 1982, NATURE, V296, P216

[5] THE STRUCTURE OF HSAG-1, A MIDDLE REPETITIVE GENETIC ELEMENT WHICH ELICITS A LEUKEMIA-RELATED CELLULAR-SURFACE ANTIGEN [J].

CHAMBERLAIN, JW ;

HENDERSON, G ;

CHANG, MWM ;

LAM, T ;

DIGNARD, D ;

LING, V ;

PRICE, GB ;

STANNERS, CP .

NUCLEIC ACIDS RESEARCH, 1986, 14 (08) :3409-3424

[6] HIGH-RESOLUTION IN SITU HYBRIDIZATION TECHNIQUE FOR THE DIRECT VISUALIZATION OF LABELED G-BANDED EARLY METAPHASE AND PROPHASE CHROMOSOMES [J].

CHANDLER, ME ;

YUNIS, JJ .

CYTOGENETICS AND CELL GENETICS, 1978, 22 (1-6) :352-356

[7] NUCLEOTIDE-SEQUENCE OF THE GENE FOR HUMAN-PROTHROMBIN [J].

DEGEN, SJF ;

DAVIE, EW .

BIOCHEMISTRY, 1987, 26 (19) :6165-6177

[8] RECENTLY AMPLIFIED ALU FAMILY MEMBERS SHARE A COMMON PARENTAL ALU SEQUENCE [J].

DEININGER, PL ;

SLAGEL, VK .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (10) :4566-4569

[9] TRANSCRIPTIONAL ANALYSIS OF INTERSPERSED REPETITIVE POLYMERASE-III TRANSCRIPTION UNITS IN HUMAN DNA [J].

ELDER, JT ;

PAN, J ;

DUNCAN, CH ;

WEISSMAN, SM .

NUCLEIC ACIDS RESEARCH, 1981, 9 (05) :1171-1189

[10] CONSERVATIVE AND VARIABLE CLUSTERS OF ALU-FAMILY DNA REPEATS IN HUMAN-CHROMOSOMES [J].

FILATOV, LV ;

MAMAYEVA, SE ;

TOMILIN, NV .

MOLECULAR BIOLOGY REPORTS, 1988, 13 (02) :79-84

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