UNIPARENTAL INHERITANCE OF THE MITOCHONDRIAL GENE CYTOCHROME-B IN PLASMODIUM-FALCIPARUM

被引：48

作者：

CREASEY, AM ^{[1
]}

RANFORDCARTWRIGHT, LC ^{[1
]}

MOORE, DJ ^{[1
]}

WILLIAMSON, DH ^{[1
]}

WILSON, RJM ^{[1
]}

WALLIKER, D ^{[1
]}

CARTER, R ^{[1
]}

机构：

[1] NATL INST MED RES,DIV PARASITOL,LONDON NW7 1AA,ENGLAND

来源：

CURRENT GENETICS | 1993年 / 23卷 / 04期

基金：

英国医学研究理事会;

关键词：

PLASMODIUM-FALCIPARUM; CYTOCHROME-B; UNIPARENTAL INHERITANCE; MITOCHONDRIAL;

D O I：

10.1007/BF00310900

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The inheritance of an extrachromosomal 6-kb element has been examined in the human malaria parasite Plasmodium falciparum. A single base pair difference in the cytochrome b gene from the 6-kb element of two different cloned lines of the parasite was identified, and used as a marker in a cross in the mosquito stage of the life cycle. Analysis of 59 individual hybrid oocysts resulting from this cross clearly demonstrated that inheritance of the cytochrome b gene was uniparental. This observation makes it possible to investigate the inheritance and evolution of cytoplasmic traits, including certain forms of drug resistance, in natural populations of this parasite.

引用

页码：360 / 364

页数：5

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