RED-CELL FILTERABILITY AND ERYTHROCYTE-MEMBRANE MICROVISCOSITY DURING TICLOPIDINE TREATMENT

被引：5

作者：

CAIMI, G ^{[1
]}

LOPRESTI, R ^{[1
]}

SERRA, A ^{[1
]}

FRANCAVILLA, G ^{[1
]}

CATANIA, A ^{[1
]}

SARNO, A ^{[1
]}

机构：

[1] UNIV PALERMO,INST CLIN MED & CARDIOVASC DIS,I-90134 PALERMO,ITALY

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1990年 / 18卷 / 02期

关键词：

erythrocytes; filterability; fluorescence polarization; membrane viscosity; Ticlopidine; vascular atherosclerosis;

D O I：

10.1177/030006059001800210

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of 10 days' treatment with 500 mg/day ticlopidine on the filterability of red blood cells in suspension and on the microviscosity of the red blood cell membrane was evaluated in 11 patients with vascular atherosclerosis. The results show ticlopidine to be effective in influencing the rheological measures of red cell filterability and membrane microviscosity: Filterability was increased and microviscosity was decreased. Ticlopidine also decreased the extent of fluorescence polarization. These results are discussed regarding possible mechanisms of action of ticlopidine. © 1990, SAGE Publications. All rights reserved.

引用

页码：161 / 163

页数：3

共 15 条

[11] The polarisation of flourescence light. Average life of molecules in their excited state [J].