Association between Vitamin D Level and Ischemic Heart Disease

Background- Vitamin D deficiency has been associated with many cardiovascular diseases and mortality. In this study, we aimed to investigate whether low levels of 25 hydroxy vitamin D concentrations associate with ischemic heart disease (IHD) in patients who referred for coronary angiography. Methods- We included 293 subjects: 133 without IHD (normal reported angiography) and 163 with ischemia (70% or more stenosis of at least one coronary artery documented by angiography). Basal concentrations of serum vitamin D, fasting blood sugar, triglyceride, cholesterol, LDL, and HDL were measured in both groups. Results- The two groups had no significant difference in respect to their age (56.55 vs. 61.45 years), blood pressure (123.03/73.88 vs. 123.68/73.98 mm Hg), fasting blood sugar (114.97 vs. 121.49 mg/dl), and lipid profile (P< 0.05). The medians of vitamin D concentration in the case and control groups were 40.80 and 40 nmol/lit, respectively, with the difference not constituting statistical significance (P< 0.05). After adjusting for other risk factors (age, sex, blood pressure, fasting blood sugar, and lipid profile), the association between vitamin D and ischemia remained non-significant (adjusted OR: 0.83, 95% CI: 0.37-1.85). Conclusion- This study was unable to demonstrate an association between low levels of vitamin D and IHD.