HIGHLY CHEMOSELECTIVE ACYLATION OF SUBSTITUTED AMINOPHENOLS WITH 3-(TRIMETHYLACETYL)-1,3-THIAZOLIDINE-2-THIONE

被引：10
作者：
DAI, WM
CHEUNG, YK
TANG, KW
CHOI, PY
CHUNG, SL
机构：
[1] Department of Chemistry, The Hong Kong University of Science and Technology Clear Water Bay, Kowloon
来源：
TETRAHEDRON | 1995年 / 51卷 / 45期
关键词：
D O I：
10.1016/0040-4020(95)00783-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general procedure for chemoselective acylation of substituted aminophenols has been developed. The N-acylated products 7 and 10a-h were prepared by treating me aminophenols with 3-(trimethylacetyl)-1,3-thiazolidine-2-thione (1) in refluxing THF in 70-100% yield. The eaters 8 and 13d,bj of 3- and 4-amino phenols could be obtained in 70-94% yield by treating with NaH and 1.
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页码：12263 / 12276
页数：14
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