FLUDARABINE-RELATED AUTOIMMUNE HEMOLYTIC-ANEMIA IN PATIENTS WITH CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：133

作者：

MYINT, H

COPPLESTONE, JA

ORCHARD, J

CRAIG, V

CURTIS, D

PRENTICE, AG

HAMON, MD

OSCIER, DG

HAMBLIN, TJ

机构：

[1] PLYMOUTH GEN HOSP,DEPT HAEMATOL,PLYMOUTH,DEVON,ENGLAND

[2] ALFRED HOSP,PRAHRAN,VIC 3181,AUSTRALIA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 91卷 / 02期

关键词：

CHRONIC LYMPHOCYTIC LEUKEMIA; AUTOIMMUNE HEMOLYTIC ANEMIA; FLUDARABINE; T CELLS;

D O I：

10.1111/j.1365-2141.1995.tb05300.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have treated 52 patients with chronic lymphocytic leukaemia (CLL) with fludarabine; 12 developed severe autoimmune haemolysis. Only three had previous history of haemolytic anaemia. Six out of eight patients retreated with fludarabine after control of their haemolysis developed an exacerbation of the haemolytic anaemia. The cause of autoimmune phenomena in CLL is not known, but our findings reinforce the view that they are caused by a disturbance in immunoregulatory T cells. Fludarabine is a known suppressor of T-cell function.

引用

页码：341 / 344

页数：4

共 24 条

[1]

BASTION Y, 1992, ANN ONCOL, V3, P171

[2]

BERGSAGEL DE, 1967, CAN MED ASSOC J, V96, P1615

[3]

BINET JL, 1981, CANCER-AM CANCER SOC, V48, P198, DOI 10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO

[4]

2-V

[5]

BOLDT DH, 1984, CANCER RES, V44, P4661

[6]

BYRD JC, 1994, P AN M AM SOC CLIN, V13, P304

[7]

CATOVSKY D, 1990, LYMPHOID LEUKEMIAS, P73

[8]

DIGHIERO G, 1991, BLOOD, V78, P1901

[9]

DIGHIERO G, 1993, CHRONIC LYMPHOCYTIC, P167

[10]

DIRAIMONDO F, 1993, LEUKEMIA LYMPHOMA, V11, P63

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