N-TERT-BUTYL-ALPHA-PHENYLNITRONE ADMINISTRATION FAILS TO MODIFY ALCOHOL DEPENDENCE AND ALCOHOL-INDUCED HYPERVASCULARIZATION

被引：0

作者：

LAMBLIN, F ^{[1
]}

PASCOLO, C ^{[1
]}

VERHEYDEN, C ^{[1
]}

DEWITTE, P ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN,PSYCHOBIOL LAB,1 PL CROIX SUD,B-1348 LOUVAIN,BELGIUM

来源：

ARCHIVES INTERNATIONALES DE PHYSIOLOGIE DE BIOCHIMIE ET DE BIOPHYSIQUE | 1994年 / 102卷 / 03期

关键词：

RAT; ALCOHOLIZATION; ALCOHOL INHALATION; N-TERT-BUTYL-ALPHA-PHENYLNITRONE;

D O I：

10.3109/13813459409007539

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic alcoholization by ethyl-alcohol inhalation was used to study the properties of a spin-trapping agent on different alcohol manifestations in rat. The spin-trapping agent, i.e. N-tert-butyl-alpha-phenylnitrone (PBN), was given at the dose of 32 mg/kg twice a day during the whole alcoholization procedure. The blood alcohol level, the hypermotility which accompagnied the ethanol withdrawal, the behavioral dependence as estimated by a free-choice program and the hypervascularization which is developped after a chronic pulmonary alcoholization were quantified. The rats treated with PBN differ from the control rats only by their higher blood alcohol level at the end of the chronic alcoholization while the other quantified alcohol-induced manifestations remained unchanged.

引用

页码：205 / 207

页数：3

共 6 条

[1] Cytotoxicity of Dihydroartemisinin Toward Molt-4 Cells Attenuated by N-Tert-butyl-alpha-phenylnitrone and Deferoxamine
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[2] N-tert-butyl-alpha-phenylnitrone protects against 3,4-methylenedioxymethamphetamine-induced depletion of serotonin in rats
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[3] Effect of the spin-trapping compound n-tert-butyl-alpha-phenylnitrone on protein oxidation and life span
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[4] THE FREE-RADICAL TRAPPING AGENT N-TERT-BUTYL-ALPHA-PHENYLNITRONE (PBN) ATTENUATES CEREBRAL ISCHEMIC-INJURY IN GERBILS
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[5] Melatonin and N-tert-butyl-alpha-phenylnitrone block 60-Hz magnetic field-induced DNA single and double strand breaks in rat brain cells
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[6] Prevention of hyperoxia-induced alterations in synaptosomal membrane-associated proteins by N-tert-butyl-alpha-phenylnitrone and 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol)
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Yatin, S
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