NEUROTOXICITY OF NONIONIC X-RAY CONTRAST-MEDIA AFTER INTRACISTERNAL ADMINISTRATION IN RATS

被引：19

作者：

WIBLE, JH

BARCO, SJ

SCHERRER, DE

WOJDYLA, JK

ADAMS, MD

机构：

[1] Mallinckrodt Medical Inc., St. Louis, MO 63134

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 1995年 / 19卷 / 03期

关键词：

CONTRAST MEDIA; TOXICITY; EFFECTS;

D O I：

10.1016/0720-048X(94)00599-8

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The neurotoxicity of an X-ray contrast medium appears inversely related to the hydrophilicity of the agent. To further test this hypothesis, four non-ionic X-ray contrast agents, differing in hydrophilicity, (ioversol, iopromide, iohexol and iopamidol) were injected into the cisternal magna of ether-anesthetized rats. Iopromide demonstrated an acute median lethal dose of 122 mg I/kg. Other signs of toxicity included convulsions, apnea, dyspnea and hypoactivity. In contrast, ioversol, iohexol and iopamidol caused no deaths when administered intracisternally, up to a dose of 1000 mg I/kg. Animals treated with these nonionic agents displayed signs of convulsions, apnea, dyspnea, chewing and hypoactivity. Iopromide possesses a hydrophilicity (e.g., water to octanol partition coefficient) approximately 8.5 times smaller than ioversol, 4.6 times smaller than iohexol and 2.3 times smaller than iopamidol. These data support the hypothesis that tri-iodinated X-ray contrast materials with smaller degrees of hydrophilicity produce greater toxicity to the central nervous system.

引用

页码：206 / 211

页数：6

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