ADHESION OF CEREBRAL ENDOTHELIAL-CELLS TO LYMPHOCYTES FROM PATIENTS WITH MULTIPLE-SCLEROSIS

被引：33
作者：
TSUKADA, N
MATSUDA, M
MIYAGI, K
YANAGISAWA, N
机构：
[1] Department of Neurology, Shinshu University School of Medicine, Matsumoto, (390)
来源：
AUTOIMMUNITY | 1993年 / 14卷 / 04期
关键词：
D O I：
10.3109/08916939309079236
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To investigate the factors regulating the entry of lymphocytes into the brain, we assessed the adhesion in vitro of Cr-51 labelled lymphocytes from peripheral blood of patients with multiple sclerosis (MS) to human cerebral endothelial cells, and evaluated the effect on the adhesion of endothelium activated by interferon-gamma (IFN-gamma), lipopolysaccharides (LPS), interleukin-1 (IL-1) and tumor necrosis factor (TNF). Patients with acute relapsing MS during an exacerbation showed significant increase in MNC adherence to cerebral endothelial cells as compared with controls (p<0.001). MNC adherence to cerebral endothelial cells activated by IFN-gamma or LPS, was significantly increased as compared to the controls (p<0.01). MNC adherence to endothelial cells was not blocked by antibodies against the intercellular adhesion molecule-1 (ICAM-1), but was blocked by lymphocyte function-associated antigen-1 (LFA-1). The increased adherence observed in patients with acute relapsing MS during an exacerbation would modulate the migration of lymphocytes across the blood-brain barrier (BBB).
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页码：329 / 333
页数：5
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