AMPHOTERICIN-B AND ITS DELIVERY BY LIPOSOMAL AND LIPID FORMULATIONS

被引：65

作者：

GATES, C ^{[1
]}

PINNEY, RJ ^{[1
]}

机构：

[1] UNIV LONDON,SCH PHARM,DEPT PHARMACEUT,MICROBIOL SECT,BRUNSWICK SQ,LONDON WC1N 1AX,ENGLAND

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 1993年 / 18卷 / 03期

关键词：

D O I：

10.1111/j.1365-2710.1993.tb00605.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In recent years, new formulations of the original amphotericin B preparation (Fungizone) have been devised in order to overcome toxicity problems that frequently occur. These preparations represent an improved method of drug delivery, with an increased therapeutic index and a decrease in toxicity to mammalian cell membranes. The new formulations have different physico-chemical characteristics and differ in pharmacokinetic parameters. Their effects must be compared with conventional amphotericin B to ascertain potential roles in future antifungal therapy.

引用

页码：147 / 153

页数：7

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