THE EXPRESSION AND LOCALIZATION OF MESSENGER-RNA FOR COLONY-STIMULATING FACTOR (CSF)-1 IN HUMAN TERM PLACENTA

被引：30

作者：

KANZAKI, H

YUI, J

IWAI, M

IMAI, K

KARIYA, M

HATAYAMA, H

MORI, T

GUILBERT, LJ

WEGMANN, TG

机构：

[1] Department of Gynaecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606

[2] Department of Immunology, Faculty of Medicine, University of Alberta, Edmonton

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 04期

关键词：

CSF-1 MESSENGER RNA; HUMAN PLACENTA; NORTHERN BLOTTING; INSITU HYBRIDIZATION;

D O I：

10.1093/oxfordjournals.humrep.a137691

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A 4-kb mRNA for colony-stimulating factor 1 (CSF-1) was detected in normal human placenta at term by Northern blot analysis. In-situ hybridization revealed that the mRNA for CSF-1 was localized in the mesenchymal cells of the chorionic villous stroma, but not in the trophoblasts or capillary epithelial cells. Because there are significant numbers of tissue macrophages (Hofbauer cells) in the placental stroma and because the receptor for CSF-1 (the c-fms proto-oncogene product) is known to be expressed by trophoblasts, our results suggest that CSF-1 produced by placental stromal cells may act as a growth and survival factor for human placental macrophages and trophoblasts.

引用

页码：563 / 567

页数：5

共 25 条

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