IS INHIBITION BY DIAZEPAM AND BETA-CARBOLINES OF ESTROGEN-INDUCED LUTEINIZING-HORMONE SECRETION RELATED TO SEDATIVE EFFECTS

被引：3

作者：

GARGIULO, PA ^{[1
]}

DONOSO, AO ^{[1
]}

机构：

[1] NATL UNIV CUYO,FAC CIENCIAS MED,INVEST CEREBRALES LAB,RA-5500 MENDOZA,ARGENTINA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 40卷 / 02期

关键词：

DIAZEPAM AND BETA-CARBOLINES; ESTROGEN-INDUCED LH RELEASE; SEDATION;

D O I：

10.1016/0091-3057(91)90563-H

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of diazepam (DZ) and the beta-carbolines ZK-91296 and ZK-93423 on luteinizing hormone (LH) release evoked by beta-estradiol were studied in estradiol-primed ovariectomized rats. Acute treatment with 2.5, 5 and 10 mg/kg DZ and ZK-91296 significantly blunted the LH response. ZK-93423 (1, 5 and 10 mg/kg) produced a similar effect. The inverse agonist DMCM (2 mg/kg) was unable to modify plasma LH levels in estrogen-primed, ovariectomized rats. Sedative effects were observed with doses of DZ (1 mg/kg) ineffective to blunt the LH response. In contrast, ZK-91296 (5 mg/kg) produced inhibition of LH surges in nonsedative doses. These results indicate that diazepam and beta-carboline agonists prevent the LH surge evoked by estrogen. They suggest, in addition, that the actions on LH release and their sedative effects are not directly related.

引用

页码：335 / 338

页数：4