EXPRESSION OF ACTIVINS AND TGF-BETA-1 AND BETA-2 RNAS IN EARLY POSTIMPLANTATION MOUSE EMBRYOS AND UTERINE DECIDUA

被引：100

作者：

MANOVA, K

PAYNTON, BV

BACHVAROVA, RF

机构：

[1] CORNELL UNIV,MED CTR,COLL MED,DEPT CELL BIOL & ANAT,1300 YORK AVE,NEW YORK,NY 10021

[2] BULGARIAN ACAD SCI,INST CELL BIOL & MORPHOL,BU-1113 SOFIA,BULGARIA

来源：

MECHANISMS OF DEVELOPMENT | 1992年 / 36卷 / 03期

基金：

美国国家科学基金会;

关键词：

ACTIVIN; TGF-BETA EXPRESSION; MOUSE EMBRYO; MOUSE DECIDUA;

D O I：

10.1016/0925-4773(92)90065-R

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The expression of the mesoderm inducing factors, activins and TGF-beta-s, was characterized in 5 1/2-9 1/2 day mouse embryos and implantation sites by in situ hybridization. Activin beta(A) RNA was not detected within the embryo, but is expressed in nearby decidual cells from 5 to 7 days. Thus activin A could play a role within the embryo during gastrulation. Activin beta(A) is also expressed in more mesometrially located decidual cells from 6 to 9 1/2 days. Activin beta(B) and inhibin alpha RNAs were not detected, while a control tissue was highly positive. TGF-beta-1 is expressed in the secondary decidual zone and in developing endothelial cells in the decidua and embryo. TGF-beta-2 is expressed in the mesometrial decidua at 6 1/2 days and in the midline of the cranial neural plate.

引用

页码：141 / 152

页数：12

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