8-METHOXYISOQUINOLINE DERIVATIVES THROUGH ORTHO-SELECTIVE METALATION OF 2-(3-METHOXYPHENYL)ETHYLAMINE

被引：20

作者：

SCHLOSSER, M

SIMIG, G

机构：

[1] Institut de Chimie organique de l'Université, CH-1005 Lausanne

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 17期

关键词：

D O I：

10.1016/0040-4039(91)85014-V

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Butyllithium in diethyl ether smoothly metalates 2-m-anisyl-N-pivaloylethylamine at the aromatic position flanked by the two substituents. Subsequent reaction with N,N-dimethylformamide followed by acid catalyzed cyclization and reduction gives 8-methoxy-1,2,3,4-tetrahydroisoquinoline.

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页码：1965 / 1966

页数：2

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