ROLE OF REPEATED EXPOSURE TO MORPHINE IN DETERMINING ITS AFFECTIVE PROPERTIES - PLACE AND TASTE CONDITIONING STUDIES IN RATS

被引：122
作者：
GAIARDI, M
BARTOLETTI, M
BACCHI, A
GUBELLINI, C
COSTA, M
BABBINI, M
机构：
[1] Institute of Pharmacology, University of Bologna, Bologna
来源：
PSYCHOPHARMACOLOGY | 1991年 / 103卷 / 02期
关键词：
SENSITIZATION TO DRUG REWARD; MORPHINE; PLACE CONDITIONING; TASTE CONDITIONING; ABUSE POTENTIAL; RAT;
D O I：
10.1007/BF02244201
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Male Sprague Dawley rats were injected daily with saline (morphine naive rats) or 20 mg/kg morphine (morphine experienced rats), starting at least 12 days before training. Subsequent place and taste conditioning indicated that 2.5 mg/kg morphine caused a significant increase in the amount of time spent on the least preferred side by morphine experienced but not by morphine naive rats; furthermore, saccharin consumption was markedly decreased and slightly increased by 10-20 mg/kg morphine in naive and experienced rats, respectively. It was concluded that morphine experience enhances the reinforcing efficacy of morphine and broadens the conditions under which the drug is reinforcing; thus it possibly increases morphine abuse potential.
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页码：183 / 186
页数：4
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