ROLE OF REPEATED EXPOSURE TO MORPHINE IN DETERMINING ITS AFFECTIVE PROPERTIES - PLACE AND TASTE CONDITIONING STUDIES IN RATS

被引：122

作者：

GAIARDI, M

BARTOLETTI, M

BACCHI, A

GUBELLINI, C

COSTA, M

BABBINI, M

机构：

[1] Institute of Pharmacology, University of Bologna, Bologna

来源：

PSYCHOPHARMACOLOGY | 1991年 / 103卷 / 02期

关键词：

SENSITIZATION TO DRUG REWARD; MORPHINE; PLACE CONDITIONING; TASTE CONDITIONING; ABUSE POTENTIAL; RAT;

D O I：

10.1007/BF02244201

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Male Sprague Dawley rats were injected daily with saline (morphine naive rats) or 20 mg/kg morphine (morphine experienced rats), starting at least 12 days before training. Subsequent place and taste conditioning indicated that 2.5 mg/kg morphine caused a significant increase in the amount of time spent on the least preferred side by morphine experienced but not by morphine naive rats; furthermore, saccharin consumption was markedly decreased and slightly increased by 10-20 mg/kg morphine in naive and experienced rats, respectively. It was concluded that morphine experience enhances the reinforcing efficacy of morphine and broadens the conditions under which the drug is reinforcing; thus it possibly increases morphine abuse potential.

引用

页码：183 / 186

页数：4

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