ROLE OF REPEATED EXPOSURE TO MORPHINE IN DETERMINING ITS AFFECTIVE PROPERTIES - PLACE AND TASTE CONDITIONING STUDIES IN RATS

被引：122
作者：
GAIARDI, M
BARTOLETTI, M
BACCHI, A
GUBELLINI, C
COSTA, M
BABBINI, M
机构：
[1] Institute of Pharmacology, University of Bologna, Bologna
来源：
PSYCHOPHARMACOLOGY | 1991年 / 103卷 / 02期
关键词：
SENSITIZATION TO DRUG REWARD; MORPHINE; PLACE CONDITIONING; TASTE CONDITIONING; ABUSE POTENTIAL; RAT;
D O I：
10.1007/BF02244201
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Male Sprague Dawley rats were injected daily with saline (morphine naive rats) or 20 mg/kg morphine (morphine experienced rats), starting at least 12 days before training. Subsequent place and taste conditioning indicated that 2.5 mg/kg morphine caused a significant increase in the amount of time spent on the least preferred side by morphine experienced but not by morphine naive rats; furthermore, saccharin consumption was markedly decreased and slightly increased by 10-20 mg/kg morphine in naive and experienced rats, respectively. It was concluded that morphine experience enhances the reinforcing efficacy of morphine and broadens the conditions under which the drug is reinforcing; thus it possibly increases morphine abuse potential.
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收藏
页码：183 / 186
页数：4
相关论文
共 25 条
[1]  
Barrett JE, 1986, BEHAVIORAL ANAL DRUG, P195
[2]   LONG-TERM SENSITIZATION TO THE EXCITATORY EFFECTS OF MORPHINE - A MOTILITY STUDY IN POST-DEPENDENT RATS [J].
BARTOLETTI, M ;
GAIARDI, M ;
GUBELLINI, G ;
BACCHI, A ;
BABBINI, M .
NEUROPHARMACOLOGY, 1983, 22 (10) :1193-1196
[3]   OPPOSITE MOTIVATIONAL EFFECTS OF ENDOGENOUS OPIOIDS IN BRAIN AND PERIPHERY [J].
BECHARA, A ;
VANDERKOOY, D .
NATURE, 1985, 314 (6011) :533-534
[4]  
CARR GD, 1986, PSYCHOPHARMACOLOGY, V89, P340
[5]  
CORFIELDSUMNER PK, 1978, CONT RES BEHAVIORAL, P391
[6]  
Goudie A, 1987, EXPT PSYCHOPHARMACOL, P341
[7]  
GRIFFITHS RR, 1979, CLIN PHARMACOL THER, V25, P611
[8]   AVERSIVE PROPERTIES OF OPIATE RECEPTOR BLOCKADE - EVIDENCE FOR EXCLUSIVELY CENTRAL MEDIATION IN NAIVE AND MORPHINE-DEPENDENT RATS [J].
HAND, TH ;
KOOB, GF ;
STINUS, L ;
LEMOAL, M .
BRAIN RESEARCH, 1988, 474 (02) :364-368
[9]   THE EFFECT OF POST-CONDITIONING EXPOSURE TO MORPHINE ON THE RETENTION OF A MORPHINE-INDUCED CONDITIONED TASTE-AVERSION [J].
JACOBS, WJ ;
ZELLNER, DA ;
LOLORDO, VM ;
RILEY, AL .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1981, 14 (06) :779-785
[10]  
Johanson C. E., 1981, ADV SUBSTANC ABUSE, P219
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