DISTRIBUTION OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR MESSENGER-RNA IN MOUSE-TISSUES

被引：73

作者：

FURUICHI, T ^{[1
]}

SHIOTA, C ^{[1
]}

MIKOSHIBA, K ^{[1
]}

机构：

[1] OSAKA UNIV,INST PROT RES,DIV REGULAT MACROMOLEC FUNCT,SUITA,OSAKA 565,JAPAN

来源：

FEBS LETTERS | 1990年 / 267卷 / 01期

关键词：

Cerebellum; Hybridization; in situ; Inositol 1,4,5-trisphosphate receptor; Oocyte; Second messenger; Smooth muscle;

D O I：

10.1016/0014-5793(90)80294-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Northern blot analysis demonstrated that the concentration of inositol 1,4,5-trisphosphate (IP3) receptor mRNA was greatest in cerebellar tissue. Moderate amounts of IP3 mRNA were present in brain tissue without cerebellum and tissue of the thymus, heart, lung, liver, spleen, kidney, and uterus. Small amounts of IP3 receptor mRNA were observed in skeletal muscle and testicular tissue. Regional distribution of IP3 mRNA in various tissues was also examined by in situ hybridization. A considerable amount of IP3 receptor mRNA was located in smooth muscle cells, such as those of the arteries, bronchioles, oviduct and uterus. In addition, secondary oocytes surrounded by Graafian follicles in the ovary were found to have large amounts of IP3 receptor mRNA. The present studies suggest a functional importance of the IP3 second-messenger system in these cell types. © 1990.

引用

页码：85 / 88

页数：4

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