AVERSIVE TASTE STIMULI INCREASE CGRP LEVELS IN THE GUSTATORY INSULAR CORTEX OF THE RAT

被引：13

作者：

YAMAMOTO, T ^{[1
]}

MATSUO, R ^{[1
]}

ICHIKAWA, H ^{[1
]}

WAKISAKA, S ^{[1
]}

AKAI, M ^{[1
]}

IMAI, Y ^{[1
]}

YONEHARA, N ^{[1
]}

INOKI, R ^{[1
]}

机构：

[1] OSAKA UNIV, FAC DENT, DEPT ORAL ANAT & PHARMACOL, SUITA, OSAKA 565, JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期

关键词：

Calcitonin gene-related peptide; Immunohistochemistry; Insular cortex; Radioimmunoassay; Taste;

D O I：

10.1016/0304-3940(90)90197-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Calcitonin gene-related peptide-like immunoreactivity (CGRP-IR) was surveyed immunohistochemically in the insular cortex of the rat, and the levels of insular cortical CGRP-IR were measured with the radioimmunoassay method following intraoral stimulation with various taste stimuli. CGRP-IR was localized in nerve fibers within the agranular and dysgranular insular cortices. The CGRP-IR levels in the rostral (gustatory) part of the insular cortex were increased significantly by strongly aversive taste stimuli such as quinine hydrochloride and conditioned taste stimuli (NaCl and sucrose) which animals had been taught to avoid. The results suggest that CGRP in the gustatory insular cortex is concerned with rejection or avoidance behaviors to aversive taste stimuli. © 1990.

引用

页码：167 / 172

页数：6

共 28 条

[11] Transient impairment of cholinergic function in the rat insular cortex disrupts the encoding of taste in conditioned taste aversion
Naor, C
Dudai, Y
BEHAVIOURAL BRAIN RESEARCH, 1996, 79 (1-2) : 61 - 67
[12] Blockade of nucleus basalis magnocellularis or activation of insular cortex histamine receptors disrupts formation but not retrieval of aversive taste memory
Puron-Sierra, Liliana
Sabath, Elizabeth
Nunez-Jaramillo, Luis
Isabel Miranda, Maria
NEUROBIOLOGY OF LEARNING AND MEMORY, 2010, 93 (02) : 216 - 220
[13] PLASMA AND ORGAN CATECHOLAMINE LEVELS FOLLOWING STIMULATION OF THE RAT INSULAR CORTEX
OPPENHEIMER, SM
SALEH, TM
WILSON, JX
CECHETTO, DE
BRAIN RESEARCH, 1992, 569 (02) : 221 - 228
[14] Environmental enrichment attenuates conditioned taste aversion through the restoration of BDNF levels in the insular cortex
Gutierrez-Vera, Beatriz
Rivera-Olvera, Alejandro
Escobar, Martha L.
BEHAVIOURAL BRAIN RESEARCH, 2022, 430
[15] Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat
Berman, DE
Hazvi, S
Rosenblum, K
Seger, R
Dudai, Y
JOURNAL OF NEUROSCIENCE, 1998, 18 (23) : 10037 - 10044
[16] Transient inhibition of protein synthesis in the rat insular cortex delays extinction of conditioned taste aversion with cyclosporine A
Hadamitzky, Martin
Orlowski, Kathrin
Schwitalla, Jan Claudius
Boesche, Katharina
Unteroberdoerster, Meike
Bendix, Ivo
Engler, Harald
Schedlowski, Manfred
NEUROBIOLOGY OF LEARNING AND MEMORY, 2016, 133 : 129 - 135
[17] Differential requirement of de novo Arc protein synthesis in the insular cortex and the amygdala for safe and aversive taste long-term memory formation
Guzman-Ramos, Kioko
Venkataraman, Archana
Morin, Jean-Pascal
Osorio-Gomez, Daniel
Bermudez-Rattoni, Federico
BEHAVIOURAL BRAIN RESEARCH, 2018, 342 : 89 - 93
[18] An anterograde and retrograde tract-tracing study on the projections from the thalamic gustatory area in the rat: distribution of neurons projecting to the insular cortex and amygdaloid complex
Nakashima, M
Uemura, M
Yasui, K
Ozaki, HS
Tabata, S
Taen, A
NEUROSCIENCE RESEARCH, 2000, 36 (04) : 297 - 309
[19] To-and-fro optical voltage signal propagation between the insular gustatory and parietal oral somatosensory areas in rat cortex slices
Yoshimura, H
Kato, N
Sugai, T
Honjo, M
Sato, J
Segami, N
Onoda, N
BRAIN RESEARCH, 2004, 1015 (1-2) : 114 - 121
[20] Effect of preexposure on methylphenidate-induced taste avoidance and related BDNF/TrkB activity in the insular cortex of the rat
B. Bradley Wetzell
Mirabella M. Muller
Shaun M. Flax
Heather E. King
Kathleen DeCicco-Skinner
Anthony L. Riley
Psychopharmacology, 2015, 232 : 2837 - 2847

← 1 2 3 →