Sleep and Cytokines

被引:23
作者
Davis, Christopher J.
Krueger, James M. [1 ]
机构
[1] Washington State Univ, Sleep & Performance Res Ctr, WWAMI Med Educ, 412 E Spokane Falls Blvd, Spokane, WA 99210 USA
基金
美国国家卫生研究院;
关键词
Tumor necrosis factor; Interleukin1; Sleep function; Adenosine triphosphate; Humoral regulation; Sleep homeostasis;
D O I
10.1016/j.jsmc.2012.06.006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Our knowledge of cytokine sleep mechanisms has led to a view of brain organization of sleep positing that sleep is a local property of neural networks. Cortical columns oscillate between functional states; the sleeplike state of cortical columns is promoted by multiple cytokines. Cytokine- mediated sleep mechanisms support the hypothesis that sleep serves a synaptic- connectivity function and is tightly coupled to cerebral metabolism. Cytokine release from glia is enhanced by neuronal activity via adenosine triphosphate signaling and, in turn, these cytokines activate nuclear factor kappa B, adenosine, and other downstream mechanisms thereby linking activity to local changes in state.
引用
收藏
页码:517 / +
页数:12
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