CRYPTORCHIDISM AND HOMEOTIC TRANSFORMATIONS OF SPINAL NERVES AND VERTEBRAE IN HOXA-10 MUTANT MICE

被引：132

作者：

RIJLI, FM

MATYAS, R

PELLEGRINI, M

DIERICH, A

GRUSS, P

DOLLE, P

CHAMBON, P

机构：

[1] UNIV STRASBOURG 1,COLL FRANCE,INSERM,CNRS,INST GENET & BIOL MOLEC & CELLULAIRE,F-67404 ILLKIRCH GRAFFENS,FRANCE

[2] MAX PLANCK INST BIOPHYS CHEM,DEPT MOLEC CELL BIOL,D-37077 GOTTINGEN,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 18期

关键词：

HOX GENES; SEGMENTATION; POSITIONAL INFORMATION; FERTILITY;

D O I：

10.1073/pnas.92.18.8185

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Homozygous mice mutated by homologous recombination for the AbdB-related Hoxa-10 gene are viable but display homeotic transformations of vertebrae and lumbar spinal nerves. Mutant males exhibit unilateral or bilateral criptorchidism due to developmental abnormalities of the gubernaculum, resulting in abnormal spermatogenesis and sterility, These results reveal an important role of Hoxa-10 in patterning posterior body regions and suggest that Hox genes are involved in specifying regional identity of both segmented and nonovertly segmented structures of the developing body.

引用

页码：8185 / 8189

页数：5

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