4-SUBSTITUTED PROLINE DERIVATIVES THAT INHIBIT ANGIOTENSIN-CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE-24.11

被引：17

作者：

BHAGWAT, SS ^{[1
]}

FINK, CA ^{[1
]}

GUDE, C ^{[1
]}

CHAN, K ^{[1
]}

QIAO, Y ^{[1
]}

SAKANE, Y ^{[1
]}

BERRY, C ^{[1
]}

GHAI, RD ^{[1
]}

机构：

[1] CIBA PHARMACEUT,RES DEPT,SUMMIT,NJ 07901

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(01)80694-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogs of captopril and enalapril with a thiorphan-like substituent at the 4-position of the proline ring were synthesized and found to be dual inhibitors of angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP).

引用

页码：2673 / 2676

页数：4

共 10 条

[1] SPECTROPHOTOMETRIC ASSAY AND PROPERTIES OF ANGIOTENSIN-CONVERTING ENZYME OF RABBIT LUNG [J].

CUSHMAN, DW ;

CHEUNG, HS .

BIOCHEMICAL PHARMACOLOGY, 1971, 20 (07) :1637-+

[2] DESIGN OF POTENT AND SPECIFIC INHIBITORS OF CARBOXYPEPTIDASE-A AND CARBOXYPEPTIDASE-B [J].

ONDETTI, MA ;

CONDON, ME ;

REID, J ;

SABO, EF ;

CHEUNG, HS ;

CUSHMAN, DW .

BIOCHEMISTRY, 1979, 18 (08) :1427-1430

[3] PURIFICATION AND SPECIFICITY OF A MEMBRANE-BOUND METALLOENDOPEPTIDASE FROM BOVINE PITUITARIES [J].

ORLOWSKI, M ;

WILK, S .

BIOCHEMISTRY, 1981, 20 (17) :4942-4950

[4]

ROQUES BP, 1990, TRENDS PHARMACOL SCI, V11, P245

[5]

ROQUES BP, 1993, PHARMACOL REV, V45, P87

[6] COMPLETE DIFFERENTIATION BETWEEN ENKEPHALINASE AND ANGIOTENSIN-CONVERTING ENZYME-INHIBITION BY RETRO-THIORPHAN [J].

ROQUES, BP ;

LUCASSOROCA, E ;

CHAILLET, P ;

COSTENTIN, J ;

FOURNIEZALUSKI, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (11) :3178-3182

[7] RENAL AND DEPRESSOR EFFECTS OF SQ-29,072, A NEUTRAL ENDOPEPTIDASE INHIBITOR, IN CONSCIOUS HYPERTENSIVE RATS [J].

SEYMOUR, AA ;

NORMAN, JA ;

ASAAD, MM ;

FENNELL, SA ;

SWERDEL, JN ;

LITTLE, DK ;

DORSO, CR .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1990, 16 (01) :163-172

[8] IDENTIFICATION OF PROTEASE-3.4.24.11 AS THE MAJOR ATRIAL NATRIURETIC FACTOR DEGRADING ENZYME IN THE RAT-KIDNEY [J].

SONNENBERG, JL ;

SAKANE, Y ;

JENG, AY ;

KOEHN, JA ;

ANSELL, JA ;

WENNOGLE, LP ;

GHAI, RD .

PEPTIDES, 1988, 9 (01) :173-180

[9]

WAEBER B, 1990, HYPERTENSION PATHOPH, V2, P2209

[10] RECENT DEVELOPMENTS IN THE DESIGN OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS [J].

WYVRATT, MJ ;

PATCHETT, AA .

MEDICINAL RESEARCH REVIEWS, 1985, 5 (04) :483-531

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