Identification and characterization of a new member of the TNF family that induces apoptosis

被引：2919

作者：

Wiley, SR ^{[1
]}

Schooley, K ^{[1
]}

Smolak, PJ ^{[1
]}

Din, WS ^{[1
]}

Huang, CP ^{[1
]}

Nicholl, JK ^{[1
]}

Sutherland, GR ^{[1
]}

Smith, TD ^{[1
]}

Rauch, C ^{[1
]}

Smith, CA ^{[1
]}

Goodwin, RG ^{[1
]}

机构：

[1] WOMENS & CHILDRENS HOSP,DEPT CYTOGENET & MOLEC GENET,CTR MED GENET,ADELAIDE,SA 5006,AUSTRALIA

来源：

IMMUNITY | 1995年 / 3卷 / 06期

关键词：

D O I：

10.1016/1074-7613(95)90057-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel tumor necrosis factor (TNF) family member has been cloned and characterized. This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity. TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate. The TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members. Both full-length cell surface expressed TRAIL and picomolar concentrations of soluble TRAIL rapidly induce apoptosis in a wide variety of transformed cell lines of diverse origin.

引用

页码：673 / 682

页数：10

共 46 条

[1]

ADACHI M, 1993, P NATL ACAD SCI USA, V90, P1758

[2] FAS LIGAND MEDIATES ACTIVATION-INDUCED CELL-DEATH IN HUMAN T-LYMPHOCYTES [J].

ALDERSON, MR ;

TOUGH, TW ;

DAVISSMITH, T ;

BRADDY, S ;

FALK, B ;

SCHOOLEY, KA ;

GOODWIN, RG ;

SMITH, CA ;

RAMSDELL, F ;

LYNCH, DH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :71-77

[3] CD40 LIGAND GENE DEFECTS RESPONSIBLE FOR X-LINKED HYPER-IGM SYNDROME [J].

ALLEN, RC ;

ARMITAGE, RJ ;

CONLEY, ME ;

ROSENBLATT, H ;

JENKINS, NA ;

COPELAND, NG ;

BEDELL, MA ;

EDELHOFF, S ;

DISTECHE, CM ;

SIMONEAUX, DK ;

FANSLOW, WC ;

BELMONT, J ;

SPRIGGS, MK .

SCIENCE, 1993, 259 (5097) :990-993

[4] LYMPHOTOXIN-BETA, A NOVEL MEMBER OF THE TNF FAMILY THAT FORMS A HETEROMERIC COMPLEX WITH LYMPHOTOXIN ON THE CELL-SURFACE [J].

BROWNING, JL ;

NGAMEK, A ;

LAWTON, P ;

DEMARINIS, J ;

TIZARD, R ;

CHOW, EPC ;

HESSION, C ;

OBRINEGRECO, B ;

FOLEY, SF ;

WARE, CF .

CELL, 1993, 72 (06) :847-856

[5]

CALLEN DF, 1990, ANN GENET-PARIS, V33, P219

[6]

CAYABYAB M, 1994, J IMMUNOL, V152, P1523

[7] THE ROLE OF CACHECTIN/TNF IN ENDOTOXIC-SHOCK AND CACHEXIA [J].

CERAMI, A ;

BEUTLER, B .

IMMUNOLOGY TODAY, 1988, 9 (01) :28-31

[8]

COHEN J, 1988, BONE MARROW TRANSPL, V3, P193

[9] A FAMILY OF LIGANDS FOR THE TNF RECEPTOR SUPERFAMILY [J].

COSMAN, D .

STEM CELLS, 1994, 12 (05) :440-455

[10]

CREASEY AA, 1987, CANCER RES, V47, P145

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