SYNTHESIS OF 3,3'-(1,2-ETHANEDIYL)BIS[2,3-DIHYDRO-2-SUBSTITUTED-4(1H)-QUINAZOLINONES] AND THEIR HETEROAROMATIC ANALOGS

Condensation of N, N'-ethanediylbis[2-amino]benzamide (I) with aldehydes in 1 : 2 molar proportions in hot acetic acid results in 3,3'-(1, 2-ethanediyl)bis[2, 3-dihydro-2-substituted-4(1H)-quinazolinones] (II). Dehydrogenation of II using nitrobenzene, potassium permanganate in acetone or palladium-charcoal leads to 3,3'-(1, 2-ethanediyl)bis[2-substituted-4(3H)-quinazolinones] (V). All the compounds have been characterised by elemental analyses and mass, IR and H NMR spectral data.