LYMPHOID DEVELOPMENT IN MICE CONGENITALLY LACKING T-CELL RECEPTOR-ALPHA-BETA EXPRESSING CELLS

被引：343
作者：
PHILPOTT, KL
VINEY, JL
KAY, G
RASTAN, S
GARDINER, EM
CHAE, S
HAYDAY, AC
OWEN, MJ
机构：
[1] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND
[2] MRC,CLIN RES CTR,COMPARAT BIOL SECT,HARROW HA1 3UJ,MIDDX,ENGLAND
[3] YALE UNIV,DEPT BIOL,NEW HAVEN,CT 06511
来源：
SCIENCE | 1992年 / 256卷 / 5062期
关键词：
D O I：
10.1126/science.1604321
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Vertebrate T cells express either an alpha-beta or gamma-delta T cell receptor (TCR). The developmental relatedness of the two cell types is unresolved. Alpha-beta+ T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. The precise influence of alpha-beta+ T cells on B cell development is poorly understood. To investigate the developmental effects of alpha-beta+ T cells on B cells and gamma-delta+ T cells, mice homozygous for a disrupted TCR-alpha gene were generated. The homozygotes showed elimination of alpha-beta+ T cells and the loss of thymic medullae. Despite this, gamma-delta+ T cells developed in normal numbers, and there was an increase in splenic B cells.
引用
收藏
页码：1448 / 1452
页数：5
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