CYTOTOXICITIES OF SOME FLAVONOID ANALOGS

被引：66

作者：

CUSHMAN, M

NAGARATHNAM, D

机构：

[1] Department of Medianal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 06期

关键词：

D O I：

10.1021/np50078a027

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An array of 55 flavones having a variety of substituents was evaluated for cytotoxicity in five cancer cell cultures: A-549 lung carcinoma, MCF-7 breast carcinoma, HT-29 colon adenocarcinoma, SKMEL-5 melanoma, and MLM melanoma. Fifteen of the 55 flavone derivatives were significantly active against at least one of these cell cultures, and 4'-[(t-butyldimethylsilyl)oxy]-7,8-dihydroxy-3',5'-dimethoxyflavo[40] was the most active of all. Structure-activity relationships of these compounds are discussed.

引用

页码：1656 / 1660

页数：5

共 34 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2] METHYLENEDIOXY-BENZOPYRAN ANALOGS OF PODOPHYLLOTOXIN, A NEW SYNTHETIC CLASS OF ANTIMITOTIC AGENTS THAT INHIBIT TUBULIN POLYMERIZATION [J].

BATRA, JK ;

KANG, GJ ;

JURD, L ;

HAMEL, E .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (13) :2595-2602

[3] NATURAL-PRODUCTS AS A SOURCE OF POTENTIAL CANCER CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS [J].

CASSADY, JM ;

BAIRD, WM ;

CHANG, CJ .

JOURNAL OF NATURAL PRODUCTS, 1990, 53 (01) :23-41

[4] THE EFFECTS OF THE BIOFLAVONOID QUERCETIN ON SQUAMOUS-CELL CARCINOMA OF HEAD AND NECK ORIGIN [J].

CASTILLO, MH ;

PERKINS, E ;

CAMPBELL, JH ;

DOERR, R ;

HASSETT, JM ;

KANDASWAMI, C ;

MIDDLETON, E .

AMERICAN JOURNAL OF SURGERY, 1989, 158 (04) :351-355

[5] SYNTHESIS AND PROTEIN-TYROSINE KINASE INHIBITORY ACTIVITIES OF FLAVONOID ANALOGS [J].

CUSHMAN, M ;

NAGARATHNAM, D ;

BURG, DL ;

GEAHLEN, RL .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :798-806

[6] A METHOD FOR THE FACILE SYNTHESIS OF RING-A HYDROXYLATED FLAVONES [J].

CUSHMAN, M ;

NAGARATHNAM, D .

TETRAHEDRON LETTERS, 1990, 31 (45) :6497-6500

[7]

CUSHMAN M, IN PRESS J NAT PROD

[8]

Denny W A, 1988, Drug Des Deliv, V3, P99

[9] INHIBITION OF PROTEIN-TYROSINE KINASE-ACTIVITY BY FLAVANOIDS AND RELATED-COMPOUNDS [J].

GEAHLEN, RL ;

KOONCHANOK, NM ;

MCLAUGHLIN, JL ;

PRATT, DE .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (05) :982-986

[10]

HAGIWARA M, 1988, BIOCHEM PHARMACOL, V37, P2987

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