AIDS - IMMUNOLOGICAL ABNORMALITIES FOLLOWING HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION

被引：1

作者：

BATRA, P

机构：

[1] University of California, Los Angeles, Department of Radiological Sciences, School of Medicine, UCLA Medical Center, Los Angeles, CA

来源：

JOURNAL OF THORACIC IMAGING | 1991年 / 6卷 / 04期

关键词：

D O I：

10.1097/00005382-199109000-00003

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Following human immunodeficiency virus (HIV) infection, there is an ordered progression of immunologic abnormalities that results from the selective infection of the T4 helper/inducer subset of T lymphocytes. The loss of helper T-cell function disrupts both the cellular and humoral aspects of the immune response. The T lymphocytes decrease in both number and function. The peripheral blood B lymphocytes demonstrate marked polyclonal activation and are unable to mount a serologic response to new antigens. The infected monocytes and macrophages serve as reservoirs for HIV and act as vehicles that transport the virus to target organs. Decreased activity of natural killer cells may promote progression of acquired immunodeficiency syndrome (AIDS). Factors that suppress the reaction of T and B lymphocytes to stimuli have been identified in the sera of AIDS patients. In conclusion, HIV infection causes progressive dysfunction and destruction of the entire immune system, resulting in severe opportunistic infections, neoplasms, and shortened survival of AIDS patients.

引用

页码：1 / 5

页数：5

共 35 条

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