CHANGES IN THE HEMATOPOIETIC PROGENITOR-CELL COMPARTMENT IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME

被引：40

作者：

GANSER, A ^{[1
]}

OTTMANN, OG ^{[1
]}

VONBRIESEN, H ^{[1
]}

VOLKERS, B ^{[1
]}

RUBSAMENWAIGMANN, H ^{[1
]}

HOELZER, D ^{[1
]}

机构：

[1] CHEMOTHERAPEUT FORSCHUNGINST, FRANKFURT, GERMANY

来源：

RESEARCH IN VIROLOGY | 1990年 / 141卷 / 02期

关键词：

AIDS; Bone marrow; Haematopoiesis; HIV; Progenitor cells; CD4; cells;

D O I：

10.1016/0923-2516(90)90020-J

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In order to elucidate the mechanisms responsible for the disturbances of haematopoiesis in HIV-infected individuals, bone marrow from 25 patients with either ARC or AIDS was studied. There is a stage-related decrease in CFU-GEMM, CFU-MK, BFU-E and CFU-GM, with the latter being least affected. This decrease is inversely correlated with the number of circulating CD4 cells and the CD4/CD8 ratio. Immunohistochemical and in situ hybridization studies of haematopoietic colonies failed to demonstrate HIV infection of haematopoietic cells. Neither the depletion of adherent mononuclear cells from haematopoietic cell cultures nor the addition of plasma containing antibodies against HIV gp120 could demonstrate an inhibitory effect of HIV-infected macrophages or immune-mediated progenitor cell lysis, respectively. Hence, imbalances of T-cell subpopulations appear to be mainly responsible for the progressive impairment of proliferation and differentiation of bone marrow progenitor cells observed in HIV-infected individuals. © 1990.

引用

页码：185 / 193

页数：9

共 35 条

[1] DEMONSTRATION OF CELL-SURFACE ANTIGENS AND THEIR ANTIBODIES BY PEROXIDASE-ANTIPEROXIDASE METHOD [J].