HUMAN THYMUS-LEUKEMIA-ASSOCIATED ANTIGEN IN NORMAL AND LEUKEMIC-CELLS

被引：34

作者：

CHECHIK, BE ^{[1
]}

PYKE, KW ^{[1
]}

GELFAND, EW ^{[1
]}

机构：

[1] HOSP SICK CHILDREN, DEPT IMMUNOL, RES INST, TORONTO M5G 1X8, ONTARIO, CANADA

来源：

INTERNATIONAL JOURNAL OF CANCER | 1976年 / 18卷 / 05期

关键词：

D O I：

10.1002/ijc.2910180502

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A saline extractable human thymus/leukemia-associated antigen (HThy-L) was detected in immunodiffusion using rabbit antisera raised to human thymus extracts. HThy-L was demonstrated in extracts of normal thymocytes, lymphocytes from E[erythrocyte]-rosetting T[thymus-derived]-cell lines and from the blast cells of patients with E-rosetting acute lymphoblastic leukemia. Extracts of leukemic cells from patients with acute myeloblastic leukemia and E-rosette-negative acute lymphoblastic leukemia contained significantly lower quantities of HThy-L. Only trace amounts of the antigen were detected in normal spleen, tonsil, peripheral blood, bone marrow and PHA[phytohemagglutinin]-induced lymphoblasts. HThy-L appears to be an antigen associated with the intrathymic differentiation of human T cells and a marker of leukemic cells in certain forms of acute leukemia.

引用

页码：551 / 556

页数：6

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