Elevated body mass index as a risk factor for chronic kidney disease: current perspectives

被引：42
作者：
Garland, Jocelyn S. [1 ]
机构：
[1] Queens Univ, Dept Med, Kingston, ON, Canada
来源：
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | 2014年 / 7卷
关键词：
obesity; chronic renal disease; adipokine;
D O I：
10.2147/DMSO.S46674
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chronic kidney disease (CKD) is defined by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative as the presence of reduced kidney function or kidney damage for a period of 3 months or greater. Obesity is considered a risk factor for CKD development, but its precise role in contributing to CKD and end stage kidney disease is not fully elucidated. In this narrative review, the objectives are to describe the pathogenesis of CKD in obesity, including the impact of altered adipokine secretion in obesity and CKD, and to provide an overview of the clinical studies assessing the risk of obesity and CKD development.
引用
收藏
页码：347 / 355
页数：9
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