THE DESIGN OF WATER-SOLUBLE BETA-SHEET STRUCTURE BASED ON A NUCLEATION STRATEGY

被引：45

作者：

DIAZ, H ^{[1
]}

TSANG, KY ^{[1
]}

CHOO, D ^{[1
]}

KELLY, JW ^{[1
]}

机构：

[1] TEXAS AGR EXPTL STN,DEPT MED,COLL STN,TX 77843

来源：

TETRAHEDRON | 1993年 / 49卷 / 17期

关键词：

D O I：

10.1016/S0040-4020(01)90213-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This manuscript demonstrates that incorporation of the amino acid residue 4-(2-aminoethyl)-6-dibenzofuranpropionic acid 1 is necessary but not sufficient to stabilize the beta-sheet structure of a heptapeptide in water. A sequence which facilitates intrastrand hydrophobic interactions is also important.

引用

页码：3533 / 3545

页数：13

共 55 条

[1]

ALTMANN KH, 1986, INT J PEPT PROT RES, V27, P314

[2]

BARANY G, 1980, PEPTIDES, V2, P3

[3] SYNTHESIS AND BETA-CONFORMATION OF SEQUENTIAL POLYPEPTIDES CONTAINING ARGININE, HISTIDINE, AND LEUCINE [J].