HUMAN CHROMOSOME-8 LINKAGE MAP BASED ON SHORT TANDEM REPEAT POLYMORPHISMS - EFFECT OF GENOTYPING ERRORS

被引：92
作者：
TOMFOHRDE, J
WOOD, S
SCHERTZER, M
WAGNER, MJ
WELLS, DE
PARRISH, J
SADLER, LA
BLANTON, SH
DAIGER, SP
WANG, ZY
WILKIE, PJ
WEBER, JL
机构：
[1] UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER V6T 1Z3,BC,CANADA
[2] UNIV TEXAS,HLTH SCI CTR,GRAD SCH BIOMED SCI,HOUSTON,TX 77225
来源：
GENOMICS | 1992年 / 14卷 / 01期
关键词：
D O I：
10.1016/S0888-7543(05)80297-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A linkage map consisting of 21 dinucleotide repeat polymorphisms, 1 tetranucleotide repeat polymorphism, and 3 RFLPs was constructed for human chromosome 8. The map spanned most of the chromosome length from near pter to q23-q24 on the distal portion of the long arm. The total 186 cM length of the female map was over two times the 84 cM length of the male map. Cytogenetic mapping of the polymorphisms using a panel of hybrids containing rearranged chromosomes was completely consistent with the linkage map. Special effort was made to remove as many genotyping errors, including parental phase errors, as possible. Removal of errors, in agreement with recent theoretical predictions, led to reduction of the total length of the sex-equal map by 10% from 145 to 130 cM. © 1992 Academic Press, Inc. All rights reserved.
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收藏
页码：144 / 152
页数：9
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