HEPATITIS-B DEFECTIVE VIRUS WITH REARRANGEMENTS IN THE PRES GENE DURING HBV CHRONIC INFECTION

被引：10

作者：

GERKEN, G

KREMSDORF, D

PETIT, MA

MANNS, M

ZUMBUSCHENFELDE, KHM

BRECHOT, C

机构：

[1] INSERM,U131,F-92140 CLAMART,FRANCE

[2] UNIV MAINZ,MED KLIN & POLIKLIN 1,W-6500 MAINZ,GERMANY

[3] INST PASTEUR,F-75724 PARIS 15,FRANCE

来源：

JOURNAL OF HEPATOLOGY | 1991年 / 13卷

关键词：

D O I：

10.1016/0168-8278(91)90034-9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We have found a defective form of hepatitis B in an anti-HBe positive chronic HBsAg carrier with liver cancer (HCC). Viral deletions were identified in the preS coding region using PCR and sequencing. The presence of deleted HBV forms was observed in serum, PBMC, and liver tissue. To conclude, rearrangements and deletions in the preS gene would potentially lead to an impairment in viral clearance without affecting viral penetration in liver cells, possibly accounting for chronic HBV infection.

引用

页码：S93 / S96

页数：4

共 8 条

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ALBERTI A, 1990, SPRINGER SEMIN IMMUN, V12, P5

[2]

BEASLEY RP, 1981, LANCET, V2, P1129

[3] IMMUNE BLOT ANALYSIS OF VIRAL SURFACE-PROTEINS IN SERUM AND LIVER OF PATIENTS WITH CHRONIC HEPATITIS-B VIRUS-INFECTION [J].