CLONING AND EXPRESSION OF AN INWARDLY RECTIFYING ATP-REGULATED POTASSIUM CHANNEL

被引：871
|
作者：
HO, K
NICHOLS, CG
LEDERER, WJ
LYTTON, J
VASSILEV, PM
KANAZIRSKA, MV
HEBERT, SC
机构：
[1] HARVARD UNIV, SCH MED, HARVARD CTR STUDY KIDNEY DIS, 75 FRANCIS ST, BOSTON, MA 02115 USA
[2] BRIGHAM & WOMENS HOSP, DEPT MED, DIV RENAL, MOLEC PHYSIOL & BIOPHYS LAB, BOSTON, MA 02115 USA
[3] WASHINGTON UNIV, MED CTR, SCH MED, DEPT CELL BIOL & PHYSIOL, ST LOUIS, MO 63110 USA
[4] UNIV MARYLAND, DEPT PHYSIOL, BALTIMORE, MD 21201 USA
[5] BRIGHAM & WOMENS HOSP, DEPT MED, DIV ENDOCRINE & HYPERTENS, BOSTON, MA 02115 USA
来源：
NATURE | 1993年 / 362卷 / 6415期
关键词：
D O I：
10.1038/362031a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger-gated ion channels. But the presence of an HS region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.
引用
收藏
页码：31 / 38
页数：8
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