ANGIOTENSIN II-INDUCED PROLIFERATION OF AORTIC MYOCYTES IN SPONTANEOUSLY HYPERTENSIVE RATS

被引：196
作者：
PAQUET, JL
BAUDOUINLEGROS, M
BRUNELLE, G
MEYER, P
机构：
[1] Department of Pharmacology, Hôpital Necker, Paris, 75015, U7 INSERM/URA 318 CNRS
来源：
JOURNAL OF HYPERTENSION | 1990年 / 8卷 / 06期
关键词：
Angiotensin ii; Cell proliferation; Oncogenes; Spontaneously hypertensive rat;
D O I：
10.1097/00004872-199006000-00010
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
In order to determine whether the morphological modifications observed in arterial media of spontaneously hypertensive rats (SHR) could be induced by an abnormal response of the smooth muscle cells to vasoactive agents, we studied the action of angiotensin (Ang) II on cultured aortic smooth muscle cells from both SHR and Wistar-Kyoto rats (WKY). Under our experimental conditions, Ang II exerts a mitogenic action on SHR cells, whereas its effect is very weak on WKY cells. Phospholipase C activation and c-fos and c-myc proto-oncogene expressions induced by Ang II are considerably enhanced in SHR cells, and these abnormalities may be linked to an increased number of Ang II receptors. © Current Science Ltd.
引用
收藏
页码：565 / 572
页数：8
相关论文
共 43 条
[1]   HYPERREACTIVITY OF PLATELETS FROM SPONTANEOUSLY HYPERTENSIVE RATS - ROLE OF EXTERNAL MAGNESIUM [J].
BAUDOUINLEGROS, M ;
DARD, B ;
GUICHENEY, P .
HYPERTENSION, 1986, 8 (08) :694-699
[2]   SPONTANEOUSLY HYPERTENSIVE RAT VASCULAR SMOOTH-MUSCLE CELLS IN CULTURE EXHIBIT INCREASED GROWTH AND NA+/H+ EXCHANGE [J].
BERK, BC ;
VALLEGA, G ;
MUSLIN, AJ ;
GORDON, HM ;
CANESSA, M ;
ALEXANDER, RW .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (03) :822-829
[3]   ANGIOTENSIN-II-STIMULATED PROTEIN-SYNTHESIS IN CULTURED VASCULAR SMOOTH-MUSCLE CELLS [J].
BERK, BC ;
VEKSHTEIN, V ;
GORDON, HM ;
TSUDA, T .
HYPERTENSION, 1989, 13 (04) :305-314
[4]   CHANGES IN THE LEVELS OF INOSITOL PHOSPHATES AFTER AGONIST-DEPENDENT HYDROLYSIS OF MEMBRANE PHOSPHOINOSITIDES [J].
BERRIDGE, MJ ;
DAWSON, RMC ;
DOWNES, CP ;
HESLOP, JP ;
IRVINE, RF .
BIOCHEMICAL JOURNAL, 1983, 212 (02) :473-482
[5]   DIFFERENCES IN MYOCYTE SUBPOPULATIONS FROM SEGMENTS OF THE THORACIC AORTA AND THEIR MODIFICATIONS WITH AGE AND HYPERTENSION IN THE RAT [J].
BODIN, P ;
STOCLET, JC ;
TRAVO, P .
CELL AND TISSUE RESEARCH, 1987, 247 (01) :227-231
[6]   COMPARISON OF FAST AND SLOW PRESSOR EFFECTS OF ANGIOTENSIN-II IN THE CONSCIOUS RAT [J].
BROWN, AJ ;
CASALSSTENZEL, J ;
GOFFORD, S ;
LEVER, AF ;
MORTON, JJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1981, 241 (03) :H381-H388
[7]   SMOOTH-MUSCLE CELL HYPERTROPHY AND HYPERPLASIA IN THE THORACIC AORTA OF SPONTANEOUSLY HYPERTENSIVE RATS [J].
BUCHER, B ;
TRAVO, P ;
STOCLET, JC .
CELL BIOLOGY INTERNATIONAL REPORTS, 1984, 8 (07) :567-577
[8]   EFFECTS OF ANGIOTENSIN-II AND VASOPRESSIN ON HUMAN SMOOTH-MUSCLE CELLS-INVITRO [J].
CAMPBELLBOSWELL, M ;
ROBERTSON, AL .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1981, 35 (02) :265-276
[9]  
CHABRIER PE, 1988, J BIOL CHEM, V263, P13199
[10]   SMOOTH-MUSCLE CELL IN CULTURE [J].
CHAMLEYCAMPBELL, J ;
CAMPBELL, GR ;
ROSS, R .
PHYSIOLOGICAL REVIEWS, 1979, 59 (01) :1-61
12345