Genetic nature and virulence of communityassociated methicillin-resistant Staphylococcus aureus

被引：32
作者：
Yamamoto, Tatsuo [1 ,2 ]
Hung, Wei-Chun [1 ,2 ]
Takano, Tomomi [2 ]
Nishiyama, Akihito [2 ]
机构：
[1] Int Med Educ & Res Ctr, Niigata, Japan
[2] Niigata Univ, Grad Sch Med & Dent Sci, Dept Infect Dis Control & Int Med, Div Bacteriol, Niigata, Japan
来源：
BIOMEDICINE-TAIWAN | 2013年 / 3卷 / 01期
关键词：
community-acquired methicillinresistant Staphylococcus aureus (MRSA); drug resistance; evolution; MRSA community-acquired diseases; virulence factor;
D O I：
10.1016/j.biomed.2012.12.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Methicillin-resistant Staphylococcus aureus (MRSA) emerged in 1961, just after the introduction of methicillin as a countermeasure against penicillinase-producing "multidrugresistant" S. aureus, a threat at that time. Since then, MRSA has posed a continuous threat to medical care as a major multidrug-resistant pathogen in hospitals. In 1997e1999, severe invasive infection with MRSA occurred in the community, and this attracted attention as community-associated MRSA (CA-MRSA). The evolutionary steps include species-tospecies transfer and salvage of key genetic structures, responsible for community spread, virulence, and resistance. The MRSA epidemic, including invasive diseases, in the community is dynamic. Copyright (C) 2012, China Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
引用
收藏
页码：2 / 18
页数：17
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