protein engineering;
substrate specificity;
stereoselectivity;
de novo design;
transaldolase;
biocatalysis;
D O I:
10.5936/csbj.201209016
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transaldolases are given in the second part of the mini-review.
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USA
Arzeda Corp, Seattle, WA 98102 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Althoff, Eric A.
Wang, Ling
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Wang, Ling
Jiang, Lin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USA
Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Jiang, Lin
Giger, Lars
论文数: 0引用数: 0
h-index: 0
机构:
ETH, Organ Chem Lab, CH-8093 Zurich, SwitzerlandUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Giger, Lars
Lassila, Jonathan K.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biochem, Stanford, CA 94305 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Lassila, Jonathan K.
Wang, Zhizhi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Wang, Zhizhi
Smith, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Smith, Matthew
Hari, Sanjay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Hari, Sanjay
Kast, Peter
论文数: 0引用数: 0
h-index: 0
机构:
ETH, Organ Chem Lab, CH-8093 Zurich, SwitzerlandUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Kast, Peter
Herschlag, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biochem, Stanford, CA 94305 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Herschlag, Daniel
Hilvert, Donald
论文数: 0引用数: 0
h-index: 0
机构:
ETH, Organ Chem Lab, CH-8093 Zurich, SwitzerlandUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Hilvert, Donald
Baker, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USA
Arzeda Corp, Seattle, WA 98102 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Althoff, Eric A.
Wang, Ling
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Wang, Ling
Jiang, Lin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USA
Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Jiang, Lin
Giger, Lars
论文数: 0引用数: 0
h-index: 0
机构:
ETH, Organ Chem Lab, CH-8093 Zurich, SwitzerlandUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Giger, Lars
Lassila, Jonathan K.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biochem, Stanford, CA 94305 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Lassila, Jonathan K.
Wang, Zhizhi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Wang, Zhizhi
Smith, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Smith, Matthew
Hari, Sanjay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Hari, Sanjay
Kast, Peter
论文数: 0引用数: 0
h-index: 0
机构:
ETH, Organ Chem Lab, CH-8093 Zurich, SwitzerlandUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Kast, Peter
Herschlag, Daniel
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Dept Biochem, Stanford, CA 94305 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Herschlag, Daniel
Hilvert, Donald
论文数: 0引用数: 0
h-index: 0
机构:
ETH, Organ Chem Lab, CH-8093 Zurich, SwitzerlandUniv Washington, Dept Biochem, Seattle, WA 98195 USA
Hilvert, Donald
Baker, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Biochem, Seattle, WA 98195 USA
HHMI, Dept Biochem, Seattle, WA 98195 USAUniv Washington, Dept Biochem, Seattle, WA 98195 USA