共 105 条
COMPUTATIONAL TOOLS FOR RATIONAL PROTEIN ENGINEERING OF ALDOLASES
被引:5
作者:

Widmann, Michael
论文数: 0 引用数: 0
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机构:
Univ Stuttgart, Inst Tech Biochem, D-70569 Stuttgart, Germany Univ Stuttgart, Inst Tech Biochem, D-70569 Stuttgart, Germany

Pleiss, Juergen
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h-index: 0
机构:
Univ Stuttgart, Inst Tech Biochem, D-70569 Stuttgart, Germany Univ Stuttgart, Inst Tech Biochem, D-70569 Stuttgart, Germany

Samland, Anne K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Stuttgart, Inst Microbiol, Allmandring 31, D-70569 Stuttgart, Germany Univ Stuttgart, Inst Tech Biochem, D-70569 Stuttgart, Germany
机构:
[1] Univ Stuttgart, Inst Tech Biochem, D-70569 Stuttgart, Germany
[2] Univ Stuttgart, Inst Microbiol, Allmandring 31, D-70569 Stuttgart, Germany
来源:
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
|
2012年
/
2卷
/
03期
关键词:
protein engineering;
substrate specificity;
stereoselectivity;
de novo design;
transaldolase;
biocatalysis;
D O I:
10.5936/csbj.201209016
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
In this mini-review we describe the different strategies for rational protein engineering and summarize the computational tools available. Computational tools can either be used to design focused libraries, to predict sequence-function relationships or for structure-based molecular modelling. This also includes de novo design of enzymes. Examples for protein engineering of aldolases and transaldolases are given in the second part of the mini-review.
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